65615-90-9

Basic information

• Product Name: 4-Amino-N-(tert-butoxycarbonyl)-L-phenylalanine Methyl Ester
• Synonyms: 4-Amino-N-(tert-butoxycarbonyl)-L-phenylalanine Methyl Ester;4-Amino-N-[(1,1-dimethylethoxy)carbonyl]-L-phenylalanine Methyl Ester;Methyl (2S)-3-(4-aminophenyl)-2-[(tert-butoxycarbonyl)amino]propanoate;L-Phenylalanine, 4-aMino-N-[(1,1-diMethylethoxy)carbonyl]-, Methyl ester;(S)-methyl 3-(4-aminophenyl)-2-((tert-butoxycarbonyl)amino)propanoate
• CAS NO: 65615-90-9
• Molecular Formula: C₁₅H₂₂N₂O₄
• Molecular Weight: 294.35
• Product Categories: Chemical Amines;Amines;Aromatics;Chiral Reagents
• Mol File: 65615-90-9.mol
• Article Data: 24

Chemical Properties

• Melting Point: 67-69?C
• Boiling Point: 460.159 °C at 760 mmHg
• Flash Point: 232.096 °C
• Appearance: Brown solid
• Density: 1.148
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 4-Amino-N-(tert-butoxycarbonyl)-L-phenylalanine Methyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Amino-N-(tert-butoxycarbonyl)-L-phenylalanine Methyl Ester(65615-90-9)
• EPA Substance Registry System: 4-Amino-N-(tert-butoxycarbonyl)-L-phenylalanine Methyl Ester(65615-90-9)

Safety Data

• Hazardous Substances Data: 65615-90-9(Hazardous Substances Data)

Usage

Chemical Properties

Brown Solid

Upstream product

• 93267-04-0 N-(tert-butoxycarbonyl)-L-3-iodoalanine methyl ester 
• 540-37-4 p-aminoiodobenzene 
• 69942-12-7 N-tert-butoxycarbonylserine methyl ester 
• 106-40-1 4-bromo-aniline 
• 175844-11-8 methyl (2R)-2-[(tert-butoxycarbonyl)amino]-3-bromopropionate 
• 63-91-2 L-phenylalanine 
• 67-56-1 methanol 
• 55533-24-9 L-N-tert-butoxycarbonyl-p-aminophenylalanine 
• 949-99-5 4-nitro-3-phenyl-L-alanine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 33305-77-0 Boc-Phe(p-NO₂)-OH 
• 65615-89-6 methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-nitrophenyl)propanoate 

Downstream Products

• 1448718-98-6 (S)-2-{[1-(2-amino-ethyl)-cyclopentanecarbonyl]-amino}-3-[4-(2,6-dichloro-benzoylamino)-phenyl]-propionic acid tert-butyl ester 
• 1448718-97-5 (S)-2-[[1-(2-azido-ethyl)-cyclopentanecarbonyl]-amino]-3-[4-(2,6-dichloro-benzoylamino)-phenyl]-propionic acid tert-butyl ester 
• 1449061-27-1 (S)-2-amino-3-[4-(2,6-dichloro-4-hydroxybenzoylamino)phenyl]propionic acid methyl ester hydrochloride 
• 1449061-26-0 (S)-2-tert-butoxycarbonylamino-3-[4-(2,6-dichloro-4-hydroxybenzoylamino)phenyl]propionic acid methyl ester 
• 1446513-21-8 (S)-N-((4-(2-((tert-butoxycarbonyl)amino)-3-methoxy-3-oxopropyl)phenyl)carbamoyl)-3-phenylsydnonimine 
• 1438853-31-6 methyl N-(tert-butoxycarbonyl)-4-({N-[6-(2,5-dioxo-2,5-dihydro-1H pyrrol-1-yl)hexanoyl]glycyl}amino)-L-phenylalaninate 
• 220880-36-4 (S)-2-[[1-(2-azido-ethyl)-cyclopentanecarbonyl]-amino]-3-[4-(2,6-dichloro-benzoylamino)-phenyl]-propionic acid methyl ester 
• 220878-78-4 (S)-2-[[1-(2-amino-ethyl)-cyclopentanecarbonyl]-amino]-3-[4-(2,6-dichloro-benzoylamino)-phenyl]-propionic acid 
• 220877-86-1 (S)-2-[[[1-(2-amino ethyl)cyclopentyl]carbonyl]amino]-3-[4-(2,6-dichlorobenzoylamino)phenyl]propionic acid methyl ester 
• 1191036-87-9 (S)-methyl 3-(4-(3-allylureido)phenyl)-2-(tert-butoxycarbonylamino)propanoate 
• 1449605-50-8 N-boc-N'-(2,6-difluorobenzoyl)-L-4-aminophenylalanine methyl ester 

Relevant articles and documents

Synthesis of Enantiopure Unnatural Amino Acids by Metallaphotoredox Catalysis

We describe herein a two-step process for the conversion of serine to a wide array of optically pure unnatural amino acids. This method utilizes a photocatalytic cross-electrophile coupling between a bromoalkyl intermediate and a diverse set of aryl halides to produce artificial analogues of phenylalanine, tryptophan, and histidine. The reaction is tolerant of a broad range of functionalities and can be leveraged toward the scalable synthesis of valuable pharmaceutical scaffolds via flow technology.

Tyrosine–chlorambucil conjugates facilitate cellular uptake through L-type amino acid transporter 1 (LAT1) in human breast cancer cell line MCF-7

l-type amino acid transporter 1 (LAT1) is an amino acid transporter that is overexpressed in several types of cancer and, thus, it can be a potential target for chemotherapy. The objectives of this study were to (a) synthesize LAT1-targeted chlorambucil d

Supramolecular self-assembly of chiral polyimides driven by repeat units and end groups

Pyromellitic diimides (PMDIs) are effective building blocks for the construction of supramolecular systems but are infrequently used in comparison with other electron-deficient aromatic systems. We report PMDI-based chiral polyimides that form polymeric supramolecular systems with unique self-assembly features that show time-dependent spectroscopic behaviour. Extensive investigations revealed the driving forces for the self-assembly of the polyimides. One is the complementary aromatic π-π stacking between electron-accepting PMDI and electron-donating phenyl ring in the polymer backbones, and another is the hydrogen bonding interactions of the end groups. The self-assembly is readily disrupted by guest molecules with strong associations with the PMDI and the end groups. The introduction of flexible arylether diimides into the PMDI-based copolymer backbones and the sequence of PMDIs and arylether diimides in the copolymer backbones significantly influence the self-assembly of the polyimides. The results elucidate the mechanisms of polymeric self-assembly of chiral polyimides, providing important information for the development of materials based on polymeric supramolecular systems with properties and functions regulated by composition, sequence and end groups.