Fmoc-L-β-methyl-isoleucine

Base Information

Chemical Name:Fmoc-L-β-methyl-isoleucine
CAS No.:1227750-73-3
Molecular Formula:C₂₂H₂₅NO₄
Molecular Weight:367.445
Hs Code.:

Synonyms:Fmoc-L-β-methyl-isoleucine

Suppliers and Price of Fmoc-L-β-methyl-isoleucine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Iris Biotech GmbH
Fmoc-beta-Me-L-Ile-OH
5 g
$ 2565.00

Iris Biotech GmbH
Fmoc-beta-Me-L-Ile-OH
1 g
$ 607.50

Iris Biotech GmbH
Fmoc-beta-Me-L-Ile-OH
250 mg
$ 202.50

Total 3 raw suppliers

Chemical Property of Fmoc-L-β-methyl-isoleucine

Chemical Property:

Boiling Point:562.7±33.0 °C(Predicted)
Density:1.189±0.06 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

Fmoc-beta-Me-L-Ile-OH ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Fmoc-L-β-methyl-isoleucine

There total 1 articles about Fmoc-L-β-methyl-isoleucine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 82911-69-1
N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

: (2S)-2-amino-3,3-dimethyl-pentanoic acid

: 1227750-73-3
Fmoc-L-β-methyl-isoleucine

Guidance literature:: With sodium hydrogencarbonate; In 1,4-dioxane; water;
DOI:10.1038/nchem.554

Reference yield:

: 1865-01-6
(4-nitrophenyl) formate

: 1227750-73-3
Fmoc-L-β-methyl-isoleucine

: 71989-31-6
Fmoc-Pro-OH

: 35661-38-2,35661-39-3,79990-15-1,136132-75-7
N-(9-fluorenylmethoxycarbonyl)-D-alanine

: 84624-17-9
N-(9-fluorenylmethoxycarbonyl)-D-valine

: 163619-04-3
1-tert-butoxycarbonyl-N-[(9-fluorenyl)methoxycarbonyl]-D-tryptophan

: 187618-60-6
Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine

: 198561-04-5
Fmoc-4-bromo-L-phenylalanine

: C₆₅H₉₀BrN₁₁O₁₄S

Guidance literature:: Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine; With 2-chlorotrityl chloride polystyrene resin; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; for 16h; 2-chlorotrityl chloride resin

With piperidine; In dichloromethane; N,N-dimethyl-formamide; 2-chlorotrityl chloride resin

(4-nitrophenyl) formate; Fmoc-L-β-methyl-isoleucine; Fmoc-Pro-OH; N-(9-fluorenylmethoxycarbonyl)-D-alanine; N-(9-fluorenylmethoxycarbonyl)-D-valine; 1-tert-butoxycarbonyl-N-[(9-fluorenyl)methoxycarbonyl]-D-tryptophan; Fmoc-4-bromo-L-phenylalanine; Further stages;
DOI:10.1021/ol502045u

Reference yield:

: 1227750-73-3
Fmoc-L-β-methyl-isoleucine

: ethyl (2S,4R)-4-[({2-[(5S,8R,10R)-1-(9H-fluoren-9-yl)-8-isopropyl-7-methyl-5-(2-methylbutan-2-yl)-3,6,12-trioxo-2,11-dioxa-4,7-diazatridecan-10-yl]-1,3-thiazol-4-yl}carbonyl)amino]-2-methyl-5-phenylpentanoate

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine; diethylamino-sulfur trifluoride / dichloromethane / 2 h / 23 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h / 0 - 23 °C / Inert atmosphere

With pyridine; diethylamino-sulfur trifluoride; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jacs.7b12692