1-methyl-2-(N-phthalimidomethyl)-5-(2'-fluoro-4'-nitrophenyl)-2H-1,4-benzodiazepine

Base Information

Chemical Name:1-methyl-2-(N-phthalimidomethyl)-5-(2'-fluoro-4'-nitrophenyl)-2H-1,4-benzodiazepine
CAS No.:127648-91-3
Molecular Formula:C₂₅H₁₉FN₄O₄
Molecular Weight:458.449
Hs Code.:

Synonyms:1-methyl-2-(N-phthalimidomethyl)-5-(2'-fluoro-4'-nitrophenyl)-2H-1,4-benzodiazepine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-methyl-2-(N-phthalimidomethyl)-5-(2'-fluoro-4'-nitrophenyl)-2H-1,4-benzodiazepine

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Technology Process of 1-methyl-2-(N-phthalimidomethyl)-5-(2'-fluoro-4'-nitrophenyl)-2H-1,4-benzodiazepine

There total 1 articles about 1-methyl-2-(N-phthalimidomethyl)-5-(2'-fluoro-4'-nitrophenyl)-2H-1,4-benzodiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1074-82-4
potassium phtalimide

: 127648-90-2
2-Chloromethyl-5-(2-fluoro-4-nitro-phenyl)-1-methyl-2,3-dihydro-1H-benzo[e][1,4]diazepine

: 127648-91-3
1-methyl-2-(N-phthalimidomethyl)-5-(2'-fluoro-4'-nitrophenyl)-2H-1,4-benzodiazepine

Guidance literature:: With potassium iodide; In methanol; for 22h; Heating;
DOI:10.1016/0223-5234(89)90022-6

Reference yield: 85.0%

: 127648-91-3
1-methyl-2-(N-phthalimidomethyl)-5-(2'-fluoro-4'-nitrophenyl)-2H-1,4-benzodiazepine

: 127648-92-4
C-[5-(2-Fluoro-4-nitro-phenyl)-1-methyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-2-yl]-methylamine

Guidance literature:: With hydrazine hydrate; In ethanol; for 4.5h; Heating;
DOI:10.1016/0223-5234(89)90022-6

Reference yield:

: 127648-91-3
1-methyl-2-(N-phthalimidomethyl)-5-(2'-fluoro-4'-nitrophenyl)-2H-1,4-benzodiazepine

: 127648-93-5
1-methyl-5-(2'-fluoro-4'-nitrophenyl)-2-(3'-thienylcarboxamido)-methyl-2H-1,4-benzodiazepine

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / 85percent hydrazine hydrate / ethanol / 4.5 h / Heating

2: 61 percent / triethylamine / CH₂Cl₂ / 3 h / Ambient temperature

With hydrazine hydrate; triethylamine; In ethanol; dichloromethane;
DOI:10.1016/0223-5234(89)90022-6