(R)-[(S)-2-[(R)-2-tert-Butoxycarbonylamino-3-(4-fluoro-3-nitro-phenyl)-propionylamino]-2-(3,5-dimethoxy-phenyl)-acetylamino]-(3-hydroxy-4-methoxy-phenyl)-acetic acid methyl ester

Base Information

Chemical Name:(R)-[(S)-2-[(R)-2-tert-Butoxycarbonylamino-3-(4-fluoro-3-nitro-phenyl)-propionylamino]-2-(3,5-dimethoxy-phenyl)-acetylamino]-(3-hydroxy-4-methoxy-phenyl)-acetic acid methyl ester
CAS No.:178217-07-7
Molecular Formula:C₃₄H₃₉FN₄O₁₂
Molecular Weight:714.702
Hs Code.:

(R)-[(S)-2-[(R)-2-tert-Butoxycarbonylamino-3-(4-fluoro-3-nitro-phenyl)-propionylamino]-2-(3,5-dimethoxy-phenyl)-acetylamino]-(3-hydroxy-4-methoxy-phenyl)-acetic acid methyl ester

Synonyms:(R)-[(S)-2-[(R)-2-tert-Butoxycarbonylamino-3-(4-fluoro-3-nitro-phenyl)-propionylamino]-2-(3,5-dimethoxy-phenyl)-acetylamino]-(3-hydroxy-4-methoxy-phenyl)-acetic acid methyl ester

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Chemical Property of (R)-[(S)-2-[(R)-2-tert-Butoxycarbonylamino-3-(4-fluoro-3-nitro-phenyl)-propionylamino]-2-(3,5-dimethoxy-phenyl)-acetylamino]-(3-hydroxy-4-methoxy-phenyl)-acetic acid methyl ester

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Technology Process of (R)-[(S)-2-[(R)-2-tert-Butoxycarbonylamino-3-(4-fluoro-3-nitro-phenyl)-propionylamino]-2-(3,5-dimethoxy-phenyl)-acetylamino]-(3-hydroxy-4-methoxy-phenyl)-acetic acid methyl ester

There total 23 articles about (R)-[(S)-2-[(R)-2-tert-Butoxycarbonylamino-3-(4-fluoro-3-nitro-phenyl)-propionylamino]-2-(3,5-dimethoxy-phenyl)-acetylamino]-(3-hydroxy-4-methoxy-phenyl)-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 173775-54-7
(R)-N-(tert-butoxycarbonyl)-4-fluoro-3-nitrophenylalanine

: 178217-04-4
(R)-[(S)-2-Amino-2-(3,5-dimethoxy-phenyl)-acetylamino]-(3-hydroxy-4-methoxy-phenyl)-acetic acid methyl ester

: 178217-07-7
(R)-[(S)-2-[(R)-2-tert-Butoxycarbonylamino-3-(4-fluoro-3-nitro-phenyl)-propionylamino]-2-(3,5-dimethoxy-phenyl)-acetylamino]-(3-hydroxy-4-methoxy-phenyl)-acetic acid methyl ester

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide;
DOI:10.1016/0040-4039(96)00459-5

Reference yield:

: 42564-51-2
4-fluoro-3-nitrobenzaldehyde

: 178217-07-7
(R)-[(S)-2-[(R)-2-tert-Butoxycarbonylamino-3-(4-fluoro-3-nitro-phenyl)-propionylamino]-2-(3,5-dimethoxy-phenyl)-acetylamino]-(3-hydroxy-4-methoxy-phenyl)-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: NaBH₄ / methanol

2: PBr₃ / diethyl ether

3: 80 percent / N-benzylcinchoninium bromide, 50 percent aq. NaOH

4: methanolic HCl

5: SOCl₂

6: NaHCO₃ / tetrahydrofuran

7: K₂CO₃ / methanol; H₂O

8: 80 percent / EDCI, HOBT / dimethylformamide

With hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; thionyl chloride; N-benzylcinchoninium bromide; phosphorus tribromide; sodium hydrogencarbonate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol; diethyl ether; water; N,N-dimethyl-formamide;
DOI:10.1016/0040-4039(96)00459-5

Reference yield:

: 7311-34-4
3,5-dimethoxybenzaldehdye

: 178217-07-7
(R)-[(S)-2-[(R)-2-tert-Butoxycarbonylamino-3-(4-fluoro-3-nitro-phenyl)-propionylamino]-2-(3,5-dimethoxy-phenyl)-acetylamino]-(3-hydroxy-4-methoxy-phenyl)-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: diethyl ether

2: AD-Mix-β / 2-methyl-propan-2-ol; H2O

3: 2,6-lutidine / dimethylformamide

4: pyridine / 0 °C

5: NaN₃ / dimethylformamide

6: TBAF / tetrahydrofuran

7: PDC / dimethylformamide

8: 90 percent / DCC, HOBT / dimethylformamide

9: H₂ / Pd/C / methanol

10: 80 percent / EDCI, HOBT / dimethylformamide

With 2,6-dimethylpyridine; dipyridinium dichromate; sodium azide; AD-mix-β; tetrabutyl ammonium fluoride; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; pyridine; methanol; diethyl ether; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/0040-4039(96)00459-5