1L-1,4,5,6-tetra-O-benzyl-4-C-benzyloxymethyl-2-desoxy-2-<(2,2,2-trichloroethoxy)carbonylamino>-muco-inosite

Base Information

• Chemical Name: 1L-1,4,5,6-tetra-O-benzyl-4-C-benzyloxymethyl-2-desoxy-2-<(2,2,2-trichloroethoxy)carbonylamino>-muco-inosite
• CAS No.: 122901-26-2
• Molecular Formula: C₄₅H₄₆Cl₃NO₈
• Molecular Weight: 835.221
• Mol file: 122901-26-2.mol

Synonyms:1L-1,4,5,6-tetra-O-benzyl-4-C-benzyloxymethyl-2-desoxy-2-<(2,2,2-trichloroethoxy)carbonylamino>-muco-inosite

Chemical Property of 1L-1,4,5,6-tetra-O-benzyl-4-C-benzyloxymethyl-2-desoxy-2-<(2,2,2-trichloroethoxy)carbonylamino>-muco-inosite

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1L-1,4,5,6-tetra-O-benzyl-4-C-benzyloxymethyl-2-desoxy-2-<(2,2,2-trichloroethoxy)carbonylamino>-muco-inosite

There total 2 articles about 1L-1,4,5,6-tetra-O-benzyl-4-C-benzyloxymethyl-2-desoxy-2-<(2,2,2-trichloroethoxy)carbonylamino>-muco-inosite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1L-2-amino-1,4,5,6-tetra-O-benzyl-4-C-bezyloxymethyl-2-desoxy-muco-inosite (122901-18-2) + 2,2,2-Trichloroethyl chloroformate (17341-93-4) → 1L-1,4,5,6-tetra-O-benzyl-4-C-benzyloxymethyl-2-desoxy-2-<(2,2,2-trichloroethoxy)carbonylamino>-muco-inosite (122901-26-2)

Guidance literature:

With potassium carbonate; In 1,4-dioxane; water; for 0.333333h;

Reference yield:

1L-2-azido-1,4,5,6-tetra-O-benzyl-2-desoxy-4-C-(benzyloxymethyl)-muco-inosit (106989-01-9) → 1L-1,4,5,6-tetra-O-benzyl-4-C-benzyloxymethyl-2-desoxy-2-<(2,2,2-trichloroethoxy)carbonylamino>-muco-inosite (122901-26-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / NaBH₄ / 4 percent NiCl₂ / ethanol

2: 95 percent / K₂CO₃ / dioxane; H₂O / 0.33 h

With sodium tetrahydroborate; potassium carbonate; nickel dichloride; In 1,4-dioxane; ethanol; water;

Reference yield: 97.0%

trifluoromethylsulfonic anhydride (358-23-6) + 1L-1,4,5,6-tetra-O-benzyl-4-C-benzyloxymethyl-2-desoxy-2-<(2,2,2-trichloroethoxy)carbonylamino>-muco-inosite (122901-26-2) → 1L-1,4,5,6-tetra-O-benzyl-4-C-benzyloxymethyl-2-desoxy-2-<(2,2,2-trichloroethoxy)carbonylamino>-3-O-<(trifluoromethyl)sulfonyl>-muco-inosite (122901-27-3)

Guidance literature:

With pyridine; In dichloromethane; at -40 ℃; for 1.5h;

upstream raw materials:

1L-2-amino-1,4,5,6-tetra-O-benzyl-4-C-bezyloxymethyl-2-desoxy-muco-inosite

2,2,2-Trichloroethyl chloroformate

1L-2-azido-1,4,5,6-tetra-O-benzyl-2-desoxy-4-C-(benzyloxymethyl)-muco-inosit

Downstream raw materials:

1L-1,4,5,6-tetra-O-benzyl-4-C-benzyloxymethyl-2-desoxy-2-<(2,2,2-trichloroethoxy)carbonylamino>-3-O-<(trifluoromethyl)sulfonyl>-muco-inosite

1L-1,4,5,6-tetra-O-benzyl-4-C-benzyloxymethyl-2,3-didesoxy-2,3-<(2,2,2-trichloroethoxy)carbonyl>epimino-epi-inosite

1L-6-azido-2,3,4,5-tetra-O-benzyl-2-C-benzyloxymethyl-1,6-didesoxy-1-<(2,2,2-trichloroethoxy)carbonylamino>-myo-inosite