4-(1-(((9H-fluoren-9-yl)methoxy)carbonyloxy)propan-2-yl)-3-nitrobenzoic acid

Base Information

• Chemical Name: 4-(1-(((9H-fluoren-9-yl)methoxy)carbonyloxy)propan-2-yl)-3-nitrobenzoic acid
• CAS No.: 1314238-42-0
• Molecular Formula: C₂₅H₂₁NO₇
• Molecular Weight: 447.444
• Mol file: 1314238-42-0.mol

Synonyms:4-(1-(((9H-fluoren-9-yl)methoxy)carbonyloxy)propan-2-yl)-3-nitrobenzoic acid

Chemical Property of 4-(1-(((9H-fluoren-9-yl)methoxy)carbonyloxy)propan-2-yl)-3-nitrobenzoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(1-(((9H-fluoren-9-yl)methoxy)carbonyloxy)propan-2-yl)-3-nitrobenzoic acid

There total 4 articles about 4-(1-(((9H-fluoren-9-yl)methoxy)carbonyloxy)propan-2-yl)-3-nitrobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

(9H-fluoren-9-yl)methyl 2-(2-nitro-4-pivaloylphenyl)propyl (1314238-41-9) → 4-(1-(((9H-fluoren-9-yl)methoxy)carbonyloxy)propan-2-yl)-3-nitrobenzoic acid (1314238-42-0)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1016/j.bmcl.2011.04.073

Reference yield:

tert-butyl 3-nitro-4-ethyl-benzoate (702642-66-8) → 4-(1-(((9H-fluoren-9-yl)methoxy)carbonyloxy)propan-2-yl)-3-nitrobenzoic acid (1314238-42-0)

Guidance literature:

Multi-step reaction with 3 steps

1: tert-butyl alcohol; potassium tert-butylate / N,N-dimethyl-formamide / 3.17 h / 20 - 90 °C

2: pyridine / acetonitrile / 16 h / Darkness

3: trifluoroacetic acid / dichloromethane / 0.5 h

With pyridine; potassium tert-butylate; trifluoroacetic acid; tert-butyl alcohol; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

tert-butyl 4-(2-hydroxy-1-methylethyl)-3-nitrobenzoate (702643-08-1) → 4-(1-(((9H-fluoren-9-yl)methoxy)carbonyloxy)propan-2-yl)-3-nitrobenzoic acid (1314238-42-0)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / acetonitrile / 16 h / Darkness

2: trifluoroacetic acid / dichloromethane / 0.5 h

With pyridine; trifluoroacetic acid; In dichloromethane; acetonitrile;

upstream raw materials:

(9H-fluoren-9-yl)methyl 2-(2-nitro-4-pivaloylphenyl)propyl

(fluorenylmethoxy)carbonyl chloride

tert-butyl 4-(2-hydroxy-1-methylethyl)-3-nitrobenzoate

tert-butyl 3-nitro-4-ethyl-benzoate