5-CHLORO-3-IODO-2-METHYLANILINE

Base Information

• Chemical Name: 5-CHLORO-3-IODO-2-METHYLANILINE
• CAS No.: 870606-29-4
• Molecular Formula: C7H7 Cl I N
• Molecular Weight: 267.497
• Mol file: 870606-29-4.mol

Synonyms:5-Chloro-3-iodo-2-methylaniline

Chemical Property of 5-CHLORO-3-IODO-2-METHYLANILINE

Chemical Property:

• PSA: 26.02000
• LogP: 3.41640
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

5-Chloro-3-iodo-2-methylaniline 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-CHLORO-3-IODO-2-METHYLANILINE

There total 4 articles about 5-CHLORO-3-IODO-2-METHYLANILINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

2-iodo-4-chloro-6-nitrotoluene (294190-16-2) → 5-chloro-3-iodo-2-methylaniline (870606-29-4)

Guidance literature:

2-iodo-4-chloro-6-nitrotoluene; With acetic acid; tin(ll) chloride; at 20 ℃; for 1h;

With sodium hydroxide; In diethyl ether; water; at 0 ℃;

Reference yield:

5-chloro-2-methyl-1,3-dinitro-benzene (35572-79-3) → 5-chloro-3-iodo-2-methylaniline (870606-29-4)

Guidance literature:

Multi-step reaction with 3 steps

1: diammonium sulfide / water; ethanol

2: sodium nitrite

3: nickel; hydrazine hydrate

With diammonium sulfide; nickel; hydrazine hydrate; sodium nitrite; In ethanol; water;

DOI:10.1021/acs.oprd.0c00486

Reference yield:

2,6-dinitrotoluene (606-20-2) → 5-chloro-3-iodo-2-methylaniline (870606-29-4)

Guidance literature:

Multi-step reaction with 4 steps

1: sulfuric acid; trichloroisocyanuric acid

2: diammonium sulfide / water; ethanol

3: sodium nitrite

4: nickel; hydrazine hydrate

With diammonium sulfide; trichloroisocyanuric acid; sulfuric acid; nickel; hydrazine hydrate; sodium nitrite; In ethanol; water;

DOI:10.1021/acs.oprd.0c00486

upstream raw materials:

2-iodo-4-chloro-6-nitrotoluene

2,6-dinitrotoluene

5-chloro-2-methyl-1,3-dinitro-benzene

5-chloro-2-methyl-3-nitro-aniline

Downstream raw materials:

1-(5-chloro-3-iodo-2-methylphenyl)piperazine

{2-[6-chloro-1-(phenylsulfonyl)-1H-indazol-4-yl]-1,3-oxazol-5-yl}methanol

4-[5-(bromomethyl)-1,3-oxazol-2-yl]-6-chloro-1-(phenylsulfonyl)-1H-indazole

6-chloro-4-(5-{[4-(1-methylethyl)-1-piperazinyl]methyl}-1,3-oxazol-2-yl)-1-(phenylsulfonyl)-1H-indazole

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