6-chloro-4-(5-{[4-(1-methylethyl)-1-piperazinyl]methyl}-1,3-oxazol-2-yl)-1-(phenylsulfonyl)-1H-indazole

Base Information

Chemical Name:6-chloro-4-(5-{[4-(1-methylethyl)-1-piperazinyl]methyl}-1,3-oxazol-2-yl)-1-(phenylsulfonyl)-1H-indazole
CAS No.:1254036-86-6
Molecular Formula:C₂₄H₂₆ClN₅O₃S
Molecular Weight:500.021
Hs Code.:

Synonyms:6-chloro-4-(5-{[4-(1-methylethyl)-1-piperazinyl]methyl}-1,3-oxazol-2-yl)-1-(phenylsulfonyl)-1H-indazole

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Chemical Property of 6-chloro-4-(5-{[4-(1-methylethyl)-1-piperazinyl]methyl}-1,3-oxazol-2-yl)-1-(phenylsulfonyl)-1H-indazole

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Technology Process of 6-chloro-4-(5-{[4-(1-methylethyl)-1-piperazinyl]methyl}-1,3-oxazol-2-yl)-1-(phenylsulfonyl)-1H-indazole

There total 14 articles about 6-chloro-4-(5-{[4-(1-methylethyl)-1-piperazinyl]methyl}-1,3-oxazol-2-yl)-1-(phenylsulfonyl)-1H-indazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 4318-42-7
1-(1-methylethyl)piperazine

: 1254036-84-4
4-[5-(bromomethyl)-1,3-oxazol-2-yl]-6-chloro-1-(phenylsulfonyl)-1H-indazole

: 1254036-86-6
6-chloro-4-(5-{[4-(1-methylethyl)-1-piperazinyl]methyl}-1,3-oxazol-2-yl)-1-(phenylsulfonyl)-1H-indazole

Guidance literature:: In dichloromethane; at 20 ℃; for 2h;
DOI:10.1021/acs.jmedchem.5b00767

Reference yield:

: 35572-79-3
5-chloro-2-methyl-1,3-dinitro-benzene

: 1254036-86-6
6-chloro-4-(5-{[4-(1-methylethyl)-1-piperazinyl]methyl}-1,3-oxazol-2-yl)-1-(phenylsulfonyl)-1H-indazole

Guidance literature:: Multi-step reaction with 9 steps

1.1: diammonium sulfide / water; ethanol

2.1: sodium nitrite

3.1: nickel; hydrazine hydrate

4.1: acetic acid; acetic anhydride

5.1: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / tetrahydrofuran

6.1: lithium hexamethyldisilazane; zinc(II) chloride / tetrahydrofuran / -10 °C

6.2: 60 °C

7.1: diisobutylaluminium hydride / toluene; tetrahydrofuran / 0 °C

8.1: bromine; triphenylphosphine / dichloromethane

9.1: triethylamine / dimethyl sulfoxide

With diammonium sulfide; bromine; tetra(n-butyl)ammonium hydrogensulfate; acetic anhydride; nickel; diisobutylaluminium hydride; hydrazine hydrate; acetic acid; triethylamine; triphenylphosphine; sodium hydroxide; zinc(II) chloride; lithium hexamethyldisilazane; sodium nitrite; In tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide; toluene;
DOI:10.1021/acs.oprd.0c00486

Reference yield:

: 98-09-9
benzenesulfonyl chloride

: 1254036-86-6
6-chloro-4-(5-{[4-(1-methylethyl)-1-piperazinyl]methyl}-1,3-oxazol-2-yl)-1-(phenylsulfonyl)-1H-indazole

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 10 °C / Cooling with ice; Inert atmosphere

1.2: 20 °C

2.1: triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / xylene / 2 h / 150 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / N,N-dimethyl-formamide / 0.5 h / 100 °C / microwave irradiation

4.1: diisobutylaluminium hydride / dichloromethane / 3 h / -25 - -20 °C

5.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 3 h / 0 - 20 °C

6.1: dichloromethane / 1.25 h / 22 °C / Inert atmosphere

With carbon tetrabromide; sodium hydride; diisobutylaluminium hydride; triethylamine; triphenylphosphine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; N,N-dimethyl-formamide; xylene;