2-CHLOROPHENYLBORONIC ACID, PINACOL ESTER

Base Information

• Chemical Name: 2-CHLOROPHENYLBORONIC ACID, PINACOL ESTER
• CAS No.: 870195-94-1
• Molecular Formula: C12H16 B Cl O2
• Molecular Weight: 238.522
• Hs Code.: 2934999090
• Mol file: 870195-94-1.mol

Synonyms:AKOS BRN-1130;2-CHLOROPHENYLBORONIC ACID, PINACOL ESTER

Chemical Property of 2-CHLOROPHENYLBORONIC ACID, PINACOL ESTER

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.506
• Boiling Point: 140-145 0,05mm
• Flash Point: 144.276°C
• PSA: 18.46000
• Density: 1.103g/cm³
• LogP: 2.63920
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

2-Chlorophenylboronic acid, pinacol ester ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 10-22
• Safety Statements: 16-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-CHLOROPHENYLBORONIC ACID, PINACOL ESTER

There total 28 articles about 2-CHLOROPHENYLBORONIC ACID, PINACOL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2-chlorobenzenediazonium tetrafluoroborate (1956-97-4) + bis(pinacol)diborane (73183-34-3) → 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-chlorobenzene (870195-94-1)

Guidance literature:

With dimanganese decacarbonyl; In acetonitrile; at 20 ℃; for 2h; Sealed tube; Inert atmosphere; Irradiation;

DOI:10.1002/chem.202004568

Reference yield: 68.0%

2-iodochlorobenzene (615-41-8) + bis(pinacol)diborane (73183-34-3) → 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-chlorobenzene (870195-94-1)

Guidance literature:

With fac-tris(2-phenylpyridinato-N,C₂')iridium(III); tributyl-amine; water; In acetonitrile; at 25 ℃; for 24h; Schlenk technique; Inert atmosphere; Sealed tube; Irradiation;

DOI:10.1021/acs.orglett.6b02553

Reference yield: 57.0%

2,3-dimethyl-2,3-butane diol (76-09-5) + diisopropopylaminoborane (22092-92-8) + 2-chlorobenzenediazonium tetrafluoroborate (1956-97-4) → 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-chlorobenzene (870195-94-1)

Guidance literature:

diisopropopylaminoborane; 2-chlorobenzenediazonium tetrafluoroborate; With bis(cyclopentadienyl)titanium dichloride; In acetonitrile; at 20 ℃; for 2.5h;

With methanol; In acetonitrile; at 0 - 20 ℃; for 1h;

2,3-dimethyl-2,3-butane diol; In diethyl ether; acetonitrile; at 20 ℃; for 4h; Reagent/catalyst;

upstream raw materials:

1,2-dichloro-benzene

4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane

chlorobenzene

bis(pinacol)diborane

Downstream raw materials:

2-monochlorophenol

1-chloro-2-(trifluoromethyl)benzene