{(3S,4S,6R,1E)-3-(4-methoxybenzyloxy)-6-(methoxymethoxy)-1-[(2S)-4-methyl-3,6-dihydro-2H-pyran-2-yl]nona-1,8-dien-4-yl} (2Z)-4-{(2R,6R)-6-[(2S)-2-methylpent-4-ynyl]-5,6-dihydro-2H-pyran-2-yl}but-2-enoate

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Chemical Name:{(3S,4S,6R,1E)-3-(4-methoxybenzyloxy)-6-(methoxymethoxy)-1-[(2S)-4-methyl-3,6-dihydro-2H-pyran-2-yl]nona-1,8-dien-4-yl} (2Z)-4-{(2R,6R)-6-[(2S)-2-methylpent-4-ynyl]-5,6-dihydro-2H-pyran-2-yl}but-2-enoate
CAS No.:1198463-37-4
Molecular Formula:C₄₀H₅₄O₈
Molecular Weight:662.864
Hs Code.:

{(3S,4S,6R,1E)-3-(4-methoxybenzyloxy)-6-(methoxymethoxy)-1-[(2S)-4-methyl-3,6-dihydro-2H-pyran-2-yl]nona-1,8-dien-4-yl} (2Z)-4-{(2R,6R)-6-[(2S)-2-methylpent-4-ynyl]-5,6-dihydro-2H-pyran-2-yl}but-2-enoate

Synonyms:{(3S,4S,6R,1E)-3-(4-methoxybenzyloxy)-6-(methoxymethoxy)-1-[(2S)-4-methyl-3,6-dihydro-2H-pyran-2-yl]nona-1,8-dien-4-yl} (2Z)-4-{(2R,6R)-6-[(2S)-2-methylpent-4-ynyl]-5,6-dihydro-2H-pyran-2-yl}but-2-enoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of {(3S,4S,6R,1E)-3-(4-methoxybenzyloxy)-6-(methoxymethoxy)-1-[(2S)-4-methyl-3,6-dihydro-2H-pyran-2-yl]nona-1,8-dien-4-yl} (2Z)-4-{(2R,6R)-6-[(2S)-2-methylpent-4-ynyl]-5,6-dihydro-2H-pyran-2-yl}but-2-enoate

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Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of {(3S,4S,6R,1E)-3-(4-methoxybenzyloxy)-6-(methoxymethoxy)-1-[(2S)-4-methyl-3,6-dihydro-2H-pyran-2-yl]nona-1,8-dien-4-yl} (2Z)-4-{(2R,6R)-6-[(2S)-2-methylpent-4-ynyl]-5,6-dihydro-2H-pyran-2-yl}but-2-enoate

There total 3 articles about {(3S,4S,6R,1E)-3-(4-methoxybenzyloxy)-6-(methoxymethoxy)-1-[(2S)-4-methyl-3,6-dihydro-2H-pyran-2-yl]nona-1,8-dien-4-yl} (2Z)-4-{(2R,6R)-6-[(2S)-2-methylpent-4-ynyl]-5,6-dihydro-2H-pyran-2-yl}but-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1198463-40-9
2-{(2R,6R)-6-[(2S)-2-methylpent-4-ynyl]-5,6-dihydro-2H-pyran-2-yl}acetaldehyde

: 1198463-38-5
(3S,4S,6R,1E)-3-(4-methoxybenzyloxy)-6-(methoxymethoxy)-1-[(2S)-4-methyl-3,6-dihydro-2H-pyran-2-yl]nona-1,8-dien-4-yl 2-[bis(2,2,2-trifluoroethoxy)phosphoryl]acetate

: 1198463-37-4
{(3S,4S,6R,1E)-3-(4-methoxybenzyloxy)-6-(methoxymethoxy)-1-[(2S)-4-methyl-3,6-dihydro-2H-pyran-2-yl]nona-1,8-dien-4-yl} (2Z)-4-{(2R,6R)-6-[(2S)-2-methylpent-4-ynyl]-5,6-dihydro-2H-pyran-2-yl}but-2-enoate

: 1198463-68-1
{(3S,4S,6R,1E)-3-(4-methoxybenzyloxy)-6-(methoxymethoxy)-1-[(2S)-4-methyl-3,6-dihydro-2H-pyran-2-yl]nona-1,8-dien-4-yl} (2E)-4-{(2R,6R)-6-[(2S)-2-methylpent-4-ynyl]-5,6-dihydro-2H-pyran-2-yl}but-2-enoate

Guidance literature:: (3S,4S,6R,1E)-3-(4-methoxybenzyloxy)-6-(methoxymethoxy)-1-[(2S)-4-methyl-3,6-dihydro-2H-pyran-2-yl]nona-1,8-dien-4-yl 2-[bis(2,2,2-trifluoroethoxy)phosphoryl]acetate; With 18-crown-6 ether; potassium hexamethylsilazane; In tetrahydrofuran; at -78 ℃; for 0.75h; Inert atmosphere;

2-{(2R,6R)-6-[(2S)-2-methylpent-4-ynyl]-5,6-dihydro-2H-pyran-2-yl}acetaldehyde; In tetrahydrofuran; at -78 ℃; optical yield given as %de; Inert atmosphere;
DOI:10.1021/ja907924j

Reference yield:

: 1198463-48-7
(3S,4S,6R,E)-3-(4-methoxybenzyloxy)-6-(methoxymethoxy)-1-[(S)-4-methyl-3,6-dihydro-2H-pyran-2-yl]nona-1,8-dien-4-ol

: 1198463-37-4
{(3S,4S,6R,1E)-3-(4-methoxybenzyloxy)-6-(methoxymethoxy)-1-[(2S)-4-methyl-3,6-dihydro-2H-pyran-2-yl]nona-1,8-dien-4-yl} (2Z)-4-{(2R,6R)-6-[(2S)-2-methylpent-4-ynyl]-5,6-dihydro-2H-pyran-2-yl}but-2-enoate

: 1198463-68-1
{(3S,4S,6R,1E)-3-(4-methoxybenzyloxy)-6-(methoxymethoxy)-1-[(2S)-4-methyl-3,6-dihydro-2H-pyran-2-yl]nona-1,8-dien-4-yl} (2E)-4-{(2R,6R)-6-[(2S)-2-methylpent-4-ynyl]-5,6-dihydro-2H-pyran-2-yl}but-2-enoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 2,4,6-trichlorobenzoyl chloride; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere

1.2: 2 h / 20 °C / Inert atmosphere

2.1: 18-crown-6 ether; potassium hexamethylsilazane / tetrahydrofuran / 0.75 h / -78 °C / Inert atmosphere

2.2: 0.42 h / Inert atmosphere

With 18-crown-6 ether; 2,4,6-trichlorobenzoyl chloride; potassium hexamethylsilazane; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 2.1: Still-Gennari olefination / 2.2: Still-Gennari olefination;
DOI:10.1002/chem.201102899

Reference yield:

: 1198463-41-0
(2R)-4-(benzyloxy)-2-[(S)-2-methylpent-4-ynyl]-3,4-dihydro-2H-pyran

: 1198463-37-4
{(3S,4S,6R,1E)-3-(4-methoxybenzyloxy)-6-(methoxymethoxy)-1-[(2S)-4-methyl-3,6-dihydro-2H-pyran-2-yl]nona-1,8-dien-4-yl} (2Z)-4-{(2R,6R)-6-[(2S)-2-methylpent-4-ynyl]-5,6-dihydro-2H-pyran-2-yl}but-2-enoate

: 1198463-68-1
{(3S,4S,6R,1E)-3-(4-methoxybenzyloxy)-6-(methoxymethoxy)-1-[(2S)-4-methyl-3,6-dihydro-2H-pyran-2-yl]nona-1,8-dien-4-yl} (2E)-4-{(2R,6R)-6-[(2S)-2-methylpent-4-ynyl]-5,6-dihydro-2H-pyran-2-yl}but-2-enoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: montmorillonite K-10 / dichloromethane / 0.75 h / 0 - 20 °C / Inert atmosphere

2.1: 18-crown-6 ether; potassium hexamethylsilazane / tetrahydrofuran / 0.75 h / -78 °C / Inert atmosphere

2.2: 0.42 h / Inert atmosphere

With 18-crown-6 ether; potassium hexamethylsilazane; In tetrahydrofuran; dichloromethane; 2.1: Still-Gennari olefination / 2.2: Still-Gennari olefination;
DOI:10.1002/chem.201102899