Tert-butyl 4-(4-formyl-1,3-thiazol-2-yl)piperidine-1-carboxylate

Base Information

Chemical Name:Tert-butyl 4-(4-formyl-1,3-thiazol-2-yl)piperidine-1-carboxylate
CAS No.:869901-02-0
Molecular Formula:C14H20 N2 O3 S
Molecular Weight:296.39
Hs Code.:2934100090
European Community (EC) Number:801-253-7
DSSTox Substance ID:DTXSID10428291
Wikidata:Q82241108
Mol file:869901-02-0.mol

Synonyms:869901-02-0;tert-Butyl 4-(4-formylthiazol-2-yl)piperidine-1-carboxylate;tert-butyl 4-(4-formyl-1,3-thiazol-2-yl)piperidine-1-carboxylate;TERT-BUTYL 4-(4-FORMYL-1,3-THIAZOL-2-YL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE;SCHEMBL192925;DTXSID10428291;tert-Butyl4-(4-formylthiazol-2-yl)piperidine-1-carboxylate;XLGKMJFDRZHAEV-UHFFFAOYSA-N;MFCD06658981;SB44119;MS-22262;CS-0319306;FT-0753236;J-524631;1,1-dimethylethyl 4-(4-formyl-2-thiazolyl)-1-piperidinecarboxylate;4-(4-Formyl-thiazol-2-yl)-piperidine-1-carboxylic acid tert-butyl ester;4-(4-formyl-2-thiazolyl)-1-piperidinecarboxylic acid, 1,1-dimethylethyl ester;4-(4-Formyl-2-thiazolyl)-1-piperidinecarboxylic acid,1,1-dimethylethyl ester;tert-Butyl 4-(4-formyl-1,3-thiazol-2-yl)tetrahydro-1(2H)-pyridinecarboxylate, AldrichCPR

Suppliers and Price of Tert-butyl 4-(4-formyl-1,3-thiazol-2-yl)piperidine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
tert-Butyl4-(4-formylthiazol-2-yl)piperidine-1-carboxylate 95+%
5g
$ 662.00

Chemenu
tert-butyl4-(4-formylthiazol-2-yl)piperidine-1-carboxylate 95%
5g
$ 626.00

American Custom Chemicals Corporation
TERT-BUTYL 4-(4-FORMYL-1,3-THIAZOL-2-YL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE 95.00%
1G
$ 907.14

American Custom Chemicals Corporation
TERT-BUTYL 4-(4-FORMYL-1,3-THIAZOL-2-YL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE 95.00%
250MG
$ 668.23

Alichem
tert-Butyl4-(4-formylthiazol-2-yl)piperidine-1-carboxylate
1g
$ 400.00

Total 10 raw suppliers

Chemical Property of Tert-butyl 4-(4-formyl-1,3-thiazol-2-yl)piperidine-1-carboxylate

Chemical Property:

Melting Point:91 °C
Boiling Point:425.0±35.0 °C(Predicted)
PKA:0.87±0.10(Predicted)
PSA：87.74000
Density:1.218±0.06 g/cm3(Predicted)
LogP:3.00800
Storage Temp.:2-8°C
XLogP3:2.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:296.11946368
Heavy Atom Count:20
Complexity:362

Purity/Quality:

98%min ^*data from raw suppliers

tert-Butyl4-(4-formylthiazol-2-yl)piperidine-1-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn
Statements: 22-37/38-41
Safety Statements: 26-39

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CCC(CC1)C2=NC(=CS2)C=O

Technology Process of Tert-butyl 4-(4-formyl-1,3-thiazol-2-yl)piperidine-1-carboxylate

There total 4 articles about Tert-butyl 4-(4-formyl-1,3-thiazol-2-yl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 864068-79-1
tert- butyl 4-(4-(hydroxymethyl)thiazol-2-yl)piperidine-1-carboxylate

: 869901-02-0
tert-butyl 4-(4-formyl-1,3-thiazol-2-yl)tetrahydro-1(2H)-pyridinecarboxylate

Guidance literature:: With Dess-Martin periodane; In dichloromethane; at 20 ℃;

Reference yield:

: 365413-31-6
ethyl 2-(1-(tert-butoxy carbonyl )piperidin-4-yl)thiazole-4-carboxylate

: 869901-02-0
tert-butyl 4-(4-formyl-1,3-thiazol-2-yl)tetrahydro-1(2H)-pyridinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate; methanol / tetrahydrofuran

2: Dess-Martin periodane / dichloromethane / 20 °C

With methanol; sodium tetrahydroborate; Dess-Martin periodane; In tetrahydrofuran; dichloromethane;

Reference yield:

: 922516-53-8
ethyl 2-(1-(tert-butoxycarbonyl)-1,2,3,6-tetrahydropyridin-4-yl)thiazole-4-carboxylate

: 869901-02-0
tert-butyl 4-(4-formyl-1,3-thiazol-2-yl)tetrahydro-1(2H)-pyridinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; hydrogen / ethanol / 12 h / 65 °C / 52505.3 Torr

2: sodium tetrahydroborate; methanol / tetrahydrofuran / 60 °C

3: Dess-Martin periodane / dichloromethane / 12 h / 20 °C

With methanol; sodium tetrahydroborate; palladium 10% on activated carbon; hydrogen; Dess-Martin periodane; In tetrahydrofuran; ethanol; dichloromethane;