methyl 2-{3-[2-(1-{[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-yl)-1,3-thiazol-4-yl]-4,5-dihydro-1,2-oxazol-5-yl}benzoate

Base Information

Chemical Name:methyl 2-{3-[2-(1-{[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-yl)-1,3-thiazol-4-yl]-4,5-dihydro-1,2-oxazol-5-yl}benzoate
CAS No.:1313009-70-9
Molecular Formula:C₂₆H₂₅F₄N₅O₄S
Molecular Weight:579.575
Hs Code.:

Synonyms:methyl 2-{3-[2-(1-{[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-yl)-1,3-thiazol-4-yl]-4,5-dihydro-1,2-oxazol-5-yl}benzoate

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Chemical Property of methyl 2-{3-[2-(1-{[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-yl)-1,3-thiazol-4-yl]-4,5-dihydro-1,2-oxazol-5-yl}benzoate

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Technology Process of methyl 2-{3-[2-(1-{[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-yl)-1,3-thiazol-4-yl]-4,5-dihydro-1,2-oxazol-5-yl}benzoate

There total 6 articles about methyl 2-{3-[2-(1-{[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-yl)-1,3-thiazol-4-yl]-4,5-dihydro-1,2-oxazol-5-yl}benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 27326-44-9
methyl o-vinylbenzoate

: 1313010-04-6
2-(1-{[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-yl)-1,3-thiazole-4-carbaldehyde oxime

: 1313009-70-9
methyl 2-{3-[2-(1-{[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-yl)-1,3-thiazol-4-yl]-4,5-dihydro-1,2-oxazol-5-yl}benzoate

: 1313009-73-2
methyl 2-{3-[2-(1-{[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-yl)-5-chloro-1,3-thiazol-4-yl]-4,5-dihydro-1,2-oxazol-5-yl}benzoate

Guidance literature:: 2-(1-{[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-yl)-1,3-thiazole-4-carbaldehyde oxime; With N-chloro-succinimide; In N,N-dimethyl-formamide; at 50 ℃; for 0.5h;

methyl o-vinylbenzoate; With triethylamine; In N,N-dimethyl-formamide; at 50 ℃; for 2h;

Reference yield:

: 512809-60-8
[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]acetic acid

: 1313009-70-9
methyl 2-{3-[2-(1-{[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-yl)-1,3-thiazol-4-yl]-4,5-dihydro-1,2-oxazol-5-yl}benzoate

: 1313009-73-2
methyl 2-{3-[2-(1-{[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-yl)-5-chloro-1,3-thiazol-4-yl]-4,5-dihydro-1,2-oxazol-5-yl}benzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 20 °C

2.1: triethylamine / dichloromethane / 3 h / 0 - 20 °C

3.1: hydroxylamine / ethanol; water / 2 h / 60 °C

4.1: N-chloro-succinimide / N,N-dimethyl-formamide / 0.5 h / 50 °C

4.2: 2 h / 50 °C

With N-chloro-succinimide; oxalyl dichloride; hydroxylamine; triethylamine; N,N-dimethyl-formamide; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1003320-03-3
2-(4-piperidinyl)-4-thiazolecarboxaldehyde monohydrochloride

: 1313009-70-9
methyl 2-{3-[2-(1-{[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-yl)-1,3-thiazol-4-yl]-4,5-dihydro-1,2-oxazol-5-yl}benzoate

: 1313009-73-2
methyl 2-{3-[2-(1-{[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-yl)-5-chloro-1,3-thiazol-4-yl]-4,5-dihydro-1,2-oxazol-5-yl}benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 3 h / 0 - 20 °C

2.1: hydroxylamine / ethanol; water / 2 h / 60 °C

3.1: N-chloro-succinimide / N,N-dimethyl-formamide / 0.5 h / 50 °C

3.2: 2 h / 50 °C

With N-chloro-succinimide; hydroxylamine; triethylamine; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;