4-(4-Chlorophenyl)-4-fluoro-1-(phenylmethyl)piperidine

Base Information

Chemical Name:4-(4-Chlorophenyl)-4-fluoro-1-(phenylmethyl)piperidine
CAS No.:324002-50-8
Molecular Formula:C₁₈H₁₉ClFN
Molecular Weight:303.807
Hs Code.:
DSSTox Substance ID:DTXSID401208851
Nikkaji Number:J1.422.439D

Synonyms:SCHEMBL654214;DTXSID401208851;324002-50-8;4-(4-Chlorophenyl)-4-fluoro-1-(phenylmethyl)piperidine

Suppliers and Price of 4-(4-Chlorophenyl)-4-fluoro-1-(phenylmethyl)piperidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(4-Chlorophenyl)-4-fluoro-1-(phenylmethyl)piperidine

Chemical Property:

XLogP3:4.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:303.1190055
Heavy Atom Count:21
Complexity:313

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CN(CCC1(C2=CC=C(C=C2)Cl)F)CC3=CC=CC=C3

Technology Process of 4-(4-Chlorophenyl)-4-fluoro-1-(phenylmethyl)piperidine

There total 6 articles about 4-(4-Chlorophenyl)-4-fluoro-1-(phenylmethyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 56108-25-9
N-benzyl-4-(4-chlorophenyl)-4-hydroxypiperidin

: 231958-20-6
4-(4-chlorophenyl)-1,2,3,6-tetrahydro-1-(phenylmethyl)-pyridine

: 324002-50-8
N-benzyl-4-(4-chlorophenyl)-4-fluoropiperidine:

Guidance literature:: With diethylamino-sulfur trifluoride; In dichloromethane; at -78 ℃; Title compound not separated from byproducts;
DOI:10.1016/S0040-4039(00)01610-5

Reference yield:

: 56108-25-9
N-benzyl-4-(4-chlorophenyl)-4-hydroxypiperidin

: 324002-50-8
N-benzyl-4-(4-chlorophenyl)-4-fluoropiperidine:

: 1-benzyl-4-(4-chloro-phenyl)-piperidine-3,4-diol

Guidance literature:: N-benzyl-4-(4-chlorophenyl)-4-hydroxypiperidin; With diethylamino-sulfur trifluoride; In dichloromethane; at -78 ℃;

With osmium(VIII) oxide; 4-methylmorpholine N-oxide; at 20 ℃;
DOI:10.1016/S0040-4039(00)01610-5

Reference yield:

: 39512-49-7
4-(4-chlorophenyl)-4-hydroxypiperidine

: 324002-50-8
N-benzyl-4-(4-chlorophenyl)-4-fluoropiperidine:

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / K₂CO₃ / dimethylformamide / 20 °C

2: diethylaminosulfur trifluoride / CH₂Cl₂ / -78 °C

With diethylamino-sulfur trifluoride; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)01610-5