56108-25-9

Usage

Uses

Used in Pharmaceutical Industry:
1-Benzyl-4-(p-chlorophenyl)-4-piperidinol is used as a key intermediate in the synthesis of various pharmaceutical compounds for its potential therapeutic applications. Its unique structural features allow it to interact with biological targets, making it a valuable component in the development of new drugs.
Used in Medicinal Chemistry Research:
1-Benzyl-4-(p-chlorophenyl)-4-piperidinol serves as a model compound in medicinal chemistry research, providing insights into the structure-activity relationships of related compounds. This understanding can guide the design of more effective and safer drugs with improved pharmacological properties.
Used in Drug Delivery Systems:
1-Benzyl-4-(p-chlorophenyl)-4-piperidinol can be incorporated into drug delivery systems to enhance the bioavailability and therapeutic efficacy of associated pharmaceuticals. Its chemical properties may allow for targeted delivery and controlled release, improving the overall effectiveness of drug treatments.

InChI:InChI=1/C18H20ClNO/c19-17-8-6-16(7-9-17)18(21)10-12-20(13-11-18)14-15-4-2-1-3-5-15/h1-9,21H,10-14H2

Upstream product

• 106-39-8 bromochlorobenzene 
• 3612-20-2 1-phenylmethyl-4-piperidone 
• 39512-49-7 4-(4-chlorophenyl)-4-hydroxypiperidine 
• 100-39-0 benzyl bromide 
• 873-77-8 (4-chlorphenyl)magnesium bromide 
• 4783-65-7 N-benzyl-2-piperidinone 
• 41979-39-9 4-piperidone hydrochloride 

Downstream Products

• 231958-20-6 4-(4-chlorophenyl)-1,2,3,6-tetrahydro-1-(phenylmethyl)-pyridine 
• 51304-61-1 4-(4-chlorophenyl)-1,2,3,6-tetrahydropyridine hydrochloride 
• 324002-50-8 N-benzyl-4-(4-chlorophenyl)-4-fluoropiperidine: 
• 1026047-44-8 1-[4-(4-Chloro-phenyl)-3,6-dihydro-2H-pyridin-1-yl]-4-(1H-indol-3-yl)-butan-1-one 
• 143682-44-4 3-{4-[4-(4-Chloro-phenyl)-3,6-dihydro-2H-pyridin-1-yl]-butyl}-1H-indole 
• 52-86-8 haloperidol 
• 39512-49-7 4-(4-chlorophenyl)-4-hydroxypiperidine 
• 143866-70-0 N-benzyl-4-(4-chlorophenyl)-piperidine 
• 26905-02-2 4-(4-chlorophenyl)piperidine 

Relevant academic research and scientific papers

Preparation method of flupiperidinol

The invention belongs to the technical field of medicine preparation, and particularly relates to a preparation method of flupiperidinol. The preparation method of the fluoropiperidinol, provided by the invention, comprises the following steps of providing 4-(4-chlorphenyl)-4-piperidinol of which the purity is 99% or above, providing 4-chloro-1-(4-fluorophenyl)butan-1-one of which the purity is more than 99%, mixing the 4-(4-chlorphenyl)-4-piperidinol, 4-chloro-1-(4-fluorophenyl)butan-1-one, an alkaline substance and a catalyst, and carrying out a first substitution reaction to obtain a crudeproduct, and mixing the crude product with an organic solvent, and sequentially carrying out reflux and crystallization to obtain the flupiperidinol. The flupiperidinol prepared according to the preparation method provided by the invention has relatively high yield and purity.

Synthesis of N-ω-phenylalkyl-4-(p-chlorophenyl)-piperidin-4-ol analogues with potent antiproliferative activity against HCT-116 cells

Some opioid analogues, such as morphine and loperamide, were reported to exhibit weak antiproliferative activity against tumor cells. In a study of loperamide analogues, we found that adding an N-ω-phenylalkyl group onto the 4-arylpiperidin-4-ol unit can have important effects on the antiproliferative activity of such compounds against HCT-116 cells. We optimized the distance between the phenyl group and 4-arylpiperidin unit to promote such activity.

CHEMOKINE RECEPTOR ANTAGONISTS AND METHODS OF USE THEREOF

Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: or physiologically acceptable salt thereof.

Triton B-mediated mild, convenient, and efficient method for the selective alkylation of cyclic secondary amines and thiols

Alkylation of cyclic secondary amines, thiols, and pyridazinones has been demonstrated with alkyl halides using Triton B as base and reaction medium.

Chemokine receptor antagonists and methods of use thereof

Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: formula (1) or physiologically acceptable salt thereof.

Chemokine receptor antagonists and methods of use therefor

Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: and physiologically acceptable salts thereof.

Chemokine receptor anagonists and methods of use therefor

Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: or physiologically acceptable salt thereof.

CHEMOKINE RECEPTOR ANTAGONISTS AND METHODS OF USE THEREFOR

Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: and physiologically acceptable salts thereof.

Pharmacophore-based discovery, synthesis, and biological evaluation of 4-phenyl-1-arylalkyl piperidines as dopamine transporter inhibitors

Pharmacophore-based discovery, synthesis, and structure-activity relationship (SAR) of a series of 4-phenyl-1-arylalkyl piperidines are disclosed. These compounds have been evaluated for their ability to inhibit reuptake of dopamine (DA) into striatal nerve endings (synaptosomes). The lead compound 5 and the most potent analogue 43 were found to have significant functional antagonism.

Synthesis of 4-substituted 4-arylpiperidines

Several novel 4-substituted 4-arylpiperidines were synthesized. The chemistry leading to 4-(4-chlorophenyl)-4-fluoropiperidine (6), 4-azido-4-(4-chlorophenyl)piperidine (7) and 4-(4-chlorophenyl)-4-methylpiperidine (8) is described. (C) 2000 Elsevier Science Ltd.