N-[5-(4-{[4-(2-hydroxyphenyl)piperazin-1-yl]carbonyl}phenyl)-4-methyl-1,3-thiazol-2-yl]guanidine

Base Information

Chemical Name:N-[5-(4-{[4-(2-hydroxyphenyl)piperazin-1-yl]carbonyl}phenyl)-4-methyl-1,3-thiazol-2-yl]guanidine
CAS No.:952750-64-0
Molecular Formula:C₂₂H₂₄N₆O₂S
Molecular Weight:436.538
Hs Code.:

Synonyms:N-[5-(4-{[4-(2-hydroxyphenyl)piperazin-1-yl]carbonyl}phenyl)-4-methyl-1,3-thiazol-2-yl]guanidine

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Chemical Property of N-[5-(4-{[4-(2-hydroxyphenyl)piperazin-1-yl]carbonyl}phenyl)-4-methyl-1,3-thiazol-2-yl]guanidine

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Technology Process of N-[5-(4-{[4-(2-hydroxyphenyl)piperazin-1-yl]carbonyl}phenyl)-4-methyl-1,3-thiazol-2-yl]guanidine

There total 5 articles about N-[5-(4-{[4-(2-hydroxyphenyl)piperazin-1-yl]carbonyl}phenyl)-4-methyl-1,3-thiazol-2-yl]guanidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 1011-17-2
2-hydroxyphenylpiperazine

: 232595-07-2
4-(2-{[amino(imino)methyl]amino}-4-methyl-1,3-thiazol-5-yl)benzoic acid

: 952750-64-0
N-[5-(4-{[4-(2-hydroxyphenyl)piperazin-1-yl]carbonyl}phenyl)-4-methyl-1,3-thiazol-2-yl]guanidine

Guidance literature:: With N,N-dimethyl-aniline; N-ethyl-N,N-diisopropylamine; HATU; at 20 ℃;

Reference yield:

: 1571-08-0
methyl 4-formylbenzoate

: 952750-64-0
N-[5-(4-{[4-(2-hydroxyphenyl)piperazin-1-yl]carbonyl}phenyl)-4-methyl-1,3-thiazol-2-yl]guanidine

Guidance literature:: Multi-step reaction with 5 steps

1.1: ammonium acetate; acetic acid / 2 h / Heating / reflux

2.1: sodium hydroxide; dihydrogen peroxide / methanol / 3.5 h / 20 °C

3.1: ethanol / 14 h / Heating / reflux

4.1: lithium hydroxide; water / tetrahydrofuran / 2 h / 50 °C

4.2: pH 1

5.1: N,N-dimethyl-aniline; N-ethyl-N,N-diisopropylamine; HATU / 20 °C

With lithium hydroxide; sodium hydroxide; ammonium acetate; water; dihydrogen peroxide; acetic acid; N,N-dimethyl-aniline; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; methanol; ethanol;

Reference yield:

: 232595-00-5
methyl (E)-4-(2-nitroprop-1-en-1-yl)benzoate

: 952750-64-0
N-[5-(4-{[4-(2-hydroxyphenyl)piperazin-1-yl]carbonyl}phenyl)-4-methyl-1,3-thiazol-2-yl]guanidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide; dihydrogen peroxide / methanol / 3.5 h / 20 °C

2.1: ethanol / 14 h / Heating / reflux

3.1: lithium hydroxide; water / tetrahydrofuran / 2 h / 50 °C

3.2: pH 1

4.1: N,N-dimethyl-aniline; N-ethyl-N,N-diisopropylamine; HATU / 20 °C

With lithium hydroxide; sodium hydroxide; water; dihydrogen peroxide; N,N-dimethyl-aniline; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; methanol; ethanol;