4‐((4‐(ethylamino)‐5‐(trifluoromethyl)pyrimidin‐2‐yl)amino)‐2‐fluoro‐5‐methoxybenzoic acid

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Chemical Name:4‐((4‐(ethylamino)‐5‐(trifluoromethyl)pyrimidin‐2‐yl)amino)‐2‐fluoro‐5‐methoxybenzoic acid
CAS No.:1401423-43-5
Molecular Formula:C₁₅H₁₄F₄N₄O₃
Molecular Weight:374.295
Hs Code.:

Synonyms:4‐((4‐(ethylamino)‐5‐(trifluoromethyl)pyrimidin‐2‐yl)amino)‐2‐fluoro‐5‐methoxybenzoic acid

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Chemical Property of 4‐((4‐(ethylamino)‐5‐(trifluoromethyl)pyrimidin‐2‐yl)amino)‐2‐fluoro‐5‐methoxybenzoic acid

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Technology Process of 4‐((4‐(ethylamino)‐5‐(trifluoromethyl)pyrimidin‐2‐yl)amino)‐2‐fluoro‐5‐methoxybenzoic acid

There total 8 articles about 4‐((4‐(ethylamino)‐5‐(trifluoromethyl)pyrimidin‐2‐yl)amino)‐2‐fluoro‐5‐methoxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: C₁₇H₁₈F₄N₄O₃

: 1401423-43-5
4‐((4‐(ethylamino)‐5‐(trifluoromethyl)pyrimidin‐2‐yl)amino)‐2‐fluoro‐5‐methoxybenzoic acid

Guidance literature:: With water; lithium hydroxide; In ethanol; at 20 ℃;
DOI:10.1002/cmdc.202000872

Reference yield:

: 1001346-91-3
4-amino-2-fluoro-5-methoxy-benzoic acid

: 1374829-47-6
2-chloro-N-ethyl-5-(trifluoromethyl)pyrimidin-4-amine

: 1401423-43-5
4‐((4‐(ethylamino)‐5‐(trifluoromethyl)pyrimidin‐2‐yl)amino)‐2‐fluoro‐5‐methoxybenzoic acid

Guidance literature:: With toluene-4-sulfonic acid; In 1,4-dioxane; at 100 ℃; for 2h;
DOI:10.1021/jm301020q

Reference yield:

: 1093847-73-4
(2-chloro-5-iodo-pyrimidin-4-yl)-ethyl-amine

: 1401423-43-5
4‐((4‐(ethylamino)‐5‐(trifluoromethyl)pyrimidin‐2‐yl)amino)‐2‐fluoro‐5‐methoxybenzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: copper(l) iodide; potassium fluoride / N,N-dimethyl-formamide; 1-methyl-pyrrolidin-2-one / 50.3 h / 35 - 150 °C / Inert atmosphere

2: toluene-4-sulfonic acid / 1,4-dioxane / 2 h / 100 °C

With potassium fluoride; copper(l) iodide; toluene-4-sulfonic acid; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide;
DOI:10.1021/jm301020q