2-Fluoro-5-methoxy-4-nitrobenzoic acid

Base Information

• Chemical Name: 2-Fluoro-5-methoxy-4-nitrobenzoic acid
• CAS No.: 1001345-80-7
• Molecular Formula: C8H6FNO5
• Molecular Weight: 215.138
• Mol file: 1001345-80-7.mol

Synonyms:2-Fluoro-5-methoxy-4-nitrobenzoic acid

Chemical Property of 2-Fluoro-5-methoxy-4-nitrobenzoic acid

Chemical Property:

• PSA: 92.35000
• LogP: 1.96390

Purity/Quality:

98%min ^*data from raw suppliers

2-Fluoro-5-methoxy-4-nitrobenzoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Fluoro-5-methoxy-4-nitrobenzoic acid

There total 4 articles about 2-Fluoro-5-methoxy-4-nitrobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + methyl 2,5-difluoro-4-nitrobenzoate (924868-81-5) → 2‐fluoro‐5‐methoxy‐4‐nitrobenzoic acid (1001345-80-7)

Guidance literature:

methanol; methyl 2,5-difluoro-4-nitrobenzoate; With potassium hydroxide; at 80 ℃; for 1h;

With hydrogenchloride; water; at 20 ℃; Product distribution / selectivity;

Reference yield: 98.0%

methanol (67-56-1) + 2,5‐difluoro‐4‐nitrobenzoic acid (116465-48-6) → 2‐fluoro‐5‐methoxy‐4‐nitrobenzoic acid (1001345-80-7)

Guidance literature:

methanol; 2,5‐difluoro‐4‐nitrobenzoic acid; With caesium carbonate; In N,N-dimethyl-formamide; at 18 - 25 ℃; for 2h;

With hydrogenchloride; In water; ethyl acetate; N,N-dimethyl-formamide; at 18 - 25 ℃; pH=1;

Reference yield: 70.0%

methanol (67-56-1) + methyl 2,5-difluoro-4-nitrobenzoate (924868-81-5) + sodium methylate (124-41-4) → 2‐fluoro‐5‐methoxy‐4‐nitrobenzoic acid (1001345-80-7)

Guidance literature:

methanol; methyl 2,5-difluoro-4-nitrobenzoate; sodium methylate; at 20 ℃;

With hydrogenchloride; water; at 20 ℃; Product distribution / selectivity;

upstream raw materials:

methanol

2,5‐difluoro‐4‐nitrobenzoic acid

methyl 2,5-difluoro-4-nitrobenzoate

sodium methylate

Downstream raw materials:

2-fluoro-5-methoxy-N-(1-methylpiperidin-4-yl)-4-nitrobenzamide

4-amino-2-fluoro-5-methoxy-benzoic acid

4-(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-ylamino)-2-fluoro-5-methoxy-benzoic acid

TAK-960

Refernces

• 1、 -. "METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION". Paragraph 0223. . Retrieved 2021/04/02.
• 2、 Nie, Zhe,Feher, Victoria,Natala, Srinivasa,McBride, Christopher,Kiryanov, Andre,Jones, Benjamin,Lam, Betty,Liu, Yan,Kaldor, Stephen,Stafford, Jeffrey,Hikami, Kouki,Uchiyama, Noriko,Kawamoto, Tomohiro,Hikichi, Yuichi,Matsumoto, Shin-Ichi,Amano, Nobuyuki,Zhang, Lilly,Hosfield, David,Skene, Robert,Zou, Hua,Cao, Xiaodong,Ichikawa, Takashi. "Discovery of TAK-960: An orally available small molecule inhibitor of polo-like kinase 1 (PLK1)". . p. 3662 - 3666. Retrieved 2013/07/05.