3-methoxy-4-[4-methoxy-2-(4-methyl-1,3-thiazol-2-yl)-3-oxobut-1-en-1-yl]benzonitrile

Base Information

• Chemical Name: 3-methoxy-4-[4-methoxy-2-(4-methyl-1,3-thiazol-2-yl)-3-oxobut-1-en-1-yl]benzonitrile
• CAS No.: 1015077-99-2
• Molecular Formula: C₁₇H₁₆N₂O₃S
• Molecular Weight: 328.392

Synonyms:3-methoxy-4-[4-methoxy-2-(4-methyl-1,3-thiazol-2-yl)-3-oxobut-1-en-1-yl]benzonitrile

Chemical Property of 3-methoxy-4-[4-methoxy-2-(4-methyl-1,3-thiazol-2-yl)-3-oxobut-1-en-1-yl]benzonitrile

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Technology Process of 3-methoxy-4-[4-methoxy-2-(4-methyl-1,3-thiazol-2-yl)-3-oxobut-1-en-1-yl]benzonitrile

There total 1 articles about 3-methoxy-4-[4-methoxy-2-(4-methyl-1,3-thiazol-2-yl)-3-oxobut-1-en-1-yl]benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

4-formyl-3-methoxy-benzonitrile (21962-45-8) + 1-Methoxy-3-(4-methyl-1,3-thiazol-2-yl)acetone (1015077-98-1) → 3-methoxy-4-[4-methoxy-2-(4-methyl-1,3-thiazol-2-yl)-3-oxobut-1-en-1-yl]benzonitrile (1015077-99-2)

Guidance literature:

With piperidine; acetic acid; In dichloromethane; Reflux;

Reference yield: 49.0%

2-aminocrotononitrile (870-64-4) + 3-methoxy-4-[4-methoxy-2-(4-methyl-1,3-thiazol-2-yl)-3-oxobut-1-en-1-yl]benzonitrile (1015077-99-2) → 4-(4-Cyano-2-methoxyphenyl)-6-(methoxymethyl)-2-methyl-5-(4-methyl-1,3-thiazol-2-yl)-1,4-di-hydropyridine-3-carbonitrile (1015077-76-5)

Guidance literature:

In isopropyl alcohol; Reflux;

Reference yield: 13.0%

3-amino-4,4,4-trifluoro-2-butenenitrile (33561-24-9) + 3-methoxy-4-[4-methoxy-2-(4-methyl-1,3-thiazol-2-yl)-3-oxobut-1-en-1-yl]benzonitrile (1015077-99-2) → 4-(4-Cyano-2-methoxyphenyl)-6-(methoxymethyl)-5-(4-methyl-1,3-thiazol-2-yl)-2-(trifluoromethyl)-1,4-dihydropyridine-3-carbonitrile (1015077-77-6,1015077-91-4,1015077-92-5)

Guidance literature:

With potassium tert-butylate; In isopropyl alcohol; Reflux;

upstream raw materials:

4-formyl-3-methoxy-benzonitrile

1-Methoxy-3-(4-methyl-1,3-thiazol-2-yl)acetone

Downstream raw materials:

4-(4-Cyano-2-methoxyphenyl)-6-(methoxymethyl)-2-methyl-5-(4-methyl-1,3-thiazol-2-yl)-1,4-di-hydropyridine-3-carbonitrile

4-(4-Cyano-2-methoxyphenyl)-6-(methoxymethyl)-5-(4-methyl-1,3-thiazol-2-yl)-2-(trifluoromethyl)-1,4-dihydropyridine-3-carbonitrile

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