21962-45-8

Usage

Uses

Used in Organic Chemistry:
4-Cyano-2-methoxybenzaldehyde is used as a synthetic intermediate for the production of various complex compounds. Its unique structure allows for the creation of a wide range of organic molecules, making it a valuable asset in the field of organic chemistry.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4-Cyano-2-methoxybenzaldehyde is used as a key building block in the synthesis of certain pharmaceutical compounds. Its versatility in forming different molecular structures contributes to the development of new drugs and therapeutic agents.
Used in Chemical Research:
4-Cyano-2-methoxybenzaldehyde is employed as a research compound in various chemical studies. Its properties and reactivity are of interest to scientists who aim to understand and explore the potential applications of 4-CYANO-2-METHOXYBENZALDEHYDE in different chemical processes and reactions.
Used in Material Science:
In the field of material science, 4-Cyano-2-methoxybenzaldehyde is used as a precursor in the development of new materials with specific properties. Its incorporation into the molecular structure of these materials can lead to the creation of materials with unique characteristics, such as improved stability or enhanced reactivity.

InChI:InChI=1/C9H7NO2/c1-12-9-4-7(5-10)2-3-8(9)6-11/h2-4,6H,1H3

Upstream product

• 959934-76-0 tert-butyl (2E)-3-(4-cyano-2-methoxyphenyl)acrylate 
• 43192-33-2 4-bromo-2-methoxybenzaldehyde 
• 7151-68-0 3-methoxy-p-toluic acid 
• 87808-44-4 3-methoxy-4-methylbenzoyl chloride 
• 139102-34-4 methyl 4-bromo-2-methoxybenzoate 
• 4421-08-3 3-methoxy-4-hydroxybenzonitrile 
• 139102-37-7 4-iodo-2-methoxybenzaldehyde 
• 38170-02-4 4-iodosalicylaldehyde 
• 626-02-8 3-Iodophenol 
• 890038-13-8 4-(hydroxymethyl)-3-methoxybenzonitrile 
• 3556-60-3 3-methoxy-4-methylcyano-benzene 

Downstream Products

• 914106-39-1 4-cyano-2-methoxybenzaldoxime 
• 914106-03-9 4-cyano-2-methoxybenzaldehyde chlorooxime 
• 914106-11-9 3-(4-cyano-2-methoxyphenyl)-5-(4-cyanophenyl)isoxazole 
• 914106-12-0 3,5-bis(4-cyano-2-methoxyphenyl)isoxazole 
• 914106-19-7 3-(4-cyano-2-methoxyphenyl)-5-(3-cyanophenyl)isoxazole 
• 914106-21-1 3-(4-cyano-2-methoxyphenyl)-5-(5-cyano-2-methoxyphenyl)isoxazole 
• 914104-59-9 3,5-bis[4-(N'-hydroxy)amidino-2-methoxyphenyl]isoxazole 
• 914104-61-3 3,5-bis[4-(N-acetoxy)amidino-2-methoxyphenyl]isoxazole 
• 914105-73-0 2,3-dibromo-3-(4-cyano-2-methoxyphenyl)-1-(4-cyanophenyl)propan-1-one 
• 914105-74-1 2,3-dibromo-3-(4-cyano-2-methoxyphenyl)-1-(3-cyanophenyl)propan-1-one 
• 914105-84-3 5-(4-cyano-2-methoxyphenyl)-3-(4-cyanophenyl)isoxazole 
• 914105-85-4 5-(4-cyano-2-methoxyphenyl)-3-(3-cyanophenyl)isoxazole 
• 316810-02-3 5,6-dichloro-2-(4-cyano-2-hydroxyphenyl)benzimidazole 
• 316810-00-1 5,6-dichloro-2-(4-cyano-2-methoxyphenyl)benzimidazole 

Relevant academic research and scientific papers

METHOD FOR THE PREPARATION OF (4S)-4-(4-CYANO-2-METHOXYPHENYL)-5-ETHOXY-2,8-DIMETHYL-1,4-DIHYDRO-1-6-NAPHTHYRIDINE-3-CARBOXAMIDE AND RECOVERY OF (4S)-4-(4-CYANO-2-METHOXYPHENYL)-5-ETHOXY-2,8-DIMETHYL-1,4-DIHYDRO-1-6-NAPHTHYRIDINE-3-CARBOXAMIDE BY ELECTROCHEMICAL METHODS

The present invention relates to a novel process for preparing (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide of the formula (I) and recovering (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide of the formula (I) proceeding from (4R)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide of the formula ent-(I)

METHOD FOR THE PREPARATION OF (4S)-4-(4-CYANO-2-METHOXYPHENYL)-5-ETHOXY-2,8-DIMETHYL-1,4-DIHYDRO-1-6-NAPHTHYRIDINE-3-CARBOXAMIDE AND THE PURIFICATION THEREOF FOR USE AS AN ACTIVE PHARMACEUTICAL INGREDIENT

The present invention relates to a novel and improved process for preparing (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide of the formula (I)

Synthesis method of 2-methoxyl-4-cyanobenzaldehyde

The invention discloses a synthesis method of 2-methoxyl-4-cyanobenzaldehyde. The method comprises the following steps: 1, carrying out acylating chlorination on 4-methyl-3-methoxybenzoic acid servingas a raw material, and then carrying out aminolysis to

METHOD FOR THE PREPARATION OF (4S)-4-(4-CYANO-2-METHOXYPHENYL)-5-ETHOXY-2,8-DIMETHYL-1,4-DIHYDRO-1-6-NAPHTHYRIDINE-3-CARBOX-AMIDE AND THE PURIFICATION THEREOF FOR USE AS AN ACTIVE PHARMACEUTICAL INGREDIENT

The present invention relates to a novel and improved process for preparing (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide of the formula (I) and also the preparation and use of the crystalline polymorph I of (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide of the formula (I).

SUBSTITUTED 4-ARYL-1,4-DIHYDRO-1,6-NAPHTHYRIDINAMIDES AND USE THEREOF

1,6-Naphthyridine or 8-azaquinazoline derivatives (I) are new. 1,6-Naphthyridine or 8-azaquinazoline derivatives of formula (I) are new. D : N or CR 4>; R 4> : H, F, CF 3 or 1-4C alkyl; Ar : 5-R 5>-6-R 6>-2-methyl-4-oxo-4H-1-benzopyran-8-yl; 3-R 6>-4-R 8>-1-naphthyl optionally substituted with 1-3 of R 7>; 7-R 6>-8-R 8>-5-quinolinyl optionally substituted with 1-2 of R 7>; or 2-R 9>-3-R 10>-4-R 8>-5-R 6>-phenyl; R 5> : H, F, Cl, CN, NO 2, CF 3 or 1-4C alkyl; R 6> : H or F; R 7> : halo, 1-4C alkyl, CF 3, 1-4C alkoxy or OCF 3; R 8> : CN or NO 2; R 9> : H or halo; optionally fluorinated 1-4C alkyl, 1-4C alkoxy, 1-4C alkylthio of di(1-4C alkyl)amino; or phenyl optionally substituted with halo, 1-4C alkyl or CF 3; R 10> : H, halo or 1-4C alkyl; R 1> : optionally fluorinated 1-4C alkyl; R 2> : 1-6C alkyl optionally substituted with 3-7C cycloalkyl or F; or SO 2R 11>; R 11> : 1-6C alkyl, CF 3 or 3-7C cycloalkyl; or phenyl or heteroaryl optionally substituted with 1-2 of halo, CN, 1-4C alkyl, CF 3, 1-4C alkoxy and/or OCF 3; R 3> : H, F, CF 3 or 1-4C alkyl. An independent claim is also included for a process for preparing (I). [Image] ACTIVITY : Hypotensive; Cardiant; Hepatotropic; Nephrotropic; Cerebroprotective. MECHANISM OF ACTION : Mineralocorticoid receptor (MR) antagonist. 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2-methyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide had an IC 50 of 35 nM when tested on cells expressing a GAL4-MR chimera.

Isothiazole and isoxazole fused pyrimidones as PDE7 inhibitors: SAR and pharmacokinetic evaluation

The synthesis and structure-activity relationship studies of isothiazole and isoxazole fused pyrimidones as PDE7 inhibitors are discussed. The pharmacokinetic profile of 10 and 21 with adequate CNS penetration, required for in vivo Parkinson's disease mod

5-ARYL-SUBSTITUTED DIHYDROPYRIDOPYRIMIDINES AND DIHYDROPYRIDAZINES AND USE THEREOF AS MINERAL CORTICOID ANTAGONISTS

The present application relates to novel aryl-substituted heterobicyclic compounds, a process for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prop

3-Cyano-5-thiazaheteroaryl-dihydropyridine and the use thereof for the treatment of cardiovascular diseases

The present application relates to novel aryl-substituted 3-cyano-5-thiazolyl- and 3-cyano-5-thiadiazolyl-1,4-dihydropyridines, a process for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially cardiovascular disorders.

SUBSTITUTED 4-ARYL-1,4-DIHYDRO-1,6-NAPHTHYRIDINES AND USE THEREOF

The present application relates to novel substituted 4-aryl-1,4-dihydro-1,6-naphthyridines, a process for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially cardiovascular disorders.

SUBSTITUTED-4-ARYL-1,4-DIHYDRO-1,6-NAPHTHYRIDINAMIDES AND USE THEREOF

The present application relates to novel substituted 4-aryl-1,4-dihydro-1,6-naphthyridine-3-carboxamides, a process for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially cardiovascular disorders.