(S)-2-(4-methylphenyl)-2-trimethylsilyloxyacetonitrile

Base Information

Chemical Name:(S)-2-(4-methylphenyl)-2-trimethylsilyloxyacetonitrile
CAS No.:191720-20-4
Molecular Formula:C₁₂H₁₇NOSi
Molecular Weight:219.359
Hs Code.:

Synonyms:(S)-2-(4-methylphenyl)-2-trimethylsilyloxyacetonitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-(4-methylphenyl)-2-trimethylsilyloxyacetonitrile

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Technology Process of (S)-2-(4-methylphenyl)-2-trimethylsilyloxyacetonitrile

There total 4 articles about (S)-2-(4-methylphenyl)-2-trimethylsilyloxyacetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 7677-24-9
trimethylsilyl cyanide

: 104-87-0
4-methyl-benzaldehyde

: 191720-20-4
(S)-2-(4-methylphenyl)-2-trimethylsilyloxyacetonitrile

Guidance literature:: With C₇₃H₉₄N₄O₁₀Ti₂*3H₂O; In dichloromethane; at 0 ℃; for 48h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1002/anie.201002127

Reference yield:

: 7677-24-9
trimethylsilyl cyanide

: 104-87-0
4-methyl-benzaldehyde

: 191720-20-4
(S)-2-(4-methylphenyl)-2-trimethylsilyloxyacetonitrile

: 139224-72-9
(R)-2-(4-methylphenyl)-2-trimethylsilyloxyacetonitrile

Guidance literature:: With samarium(III) chloride; (2S,2'S,4S,4'S,5R,5'R)-N,N'-bis(3,4,-dimethyl-2-oxo-5-phenyl-1,3,2-oxazaphospholan-2-yl)ethane-1,2-diamine; In toluene; at -15 ℃; for 24h; Product distribution; other solvent, temperature;
DOI:10.1021/jo971868j

Reference yield:

: 74-90-8
hydrogen cyanide

: 7677-24-9
trimethylsilyl cyanide

: 104-87-0
4-methyl-benzaldehyde

: 191720-20-4
(S)-2-(4-methylphenyl)-2-trimethylsilyloxyacetonitrile

Guidance literature:: hydrogen cyanide; trimethylsilyl cyanide; With titanium(IV) isopropylate; (R)-3-(1H-imidazol-1-yl)-1,1'-bi-2-naphthol; In dichloromethane; at -40 ℃; for 0.166667h; Inert atmosphere;

4-methyl-benzaldehyde; In dichloromethane; at -40 ℃; for 48h; enantioselective reaction; Inert atmosphere;
DOI:10.1002/chem.200701660