YRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLIC ACID, 2-AMINO-7,8-DIHYDRO-, 1,1-DIMETHYLETHYL ESTER

Base Information

• Chemical Name: YRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLIC ACID, 2-AMINO-7,8-DIHYDRO-, 1,1-DIMETHYLETHYL ESTER
• CAS No.: 869198-95-8
• Molecular Formula: C12H18N4O2
• Molecular Weight: 250.301
• Hs Code.: 2933990090
• Mol file: 869198-95-8.mol

Synonyms:tert-Butyl 2-amino-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxylate;2-Amino-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxylic acid tert-butyl ester;6-Boc-2-amino-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine;AC1Q1N2R;ZINC20866982;

Chemical Property of YRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLIC ACID, 2-AMINO-7,8-DIHYDRO-, 1,1-DIMETHYLETHYL ESTER

Chemical Property:

• Vapor Pressure: 4.55E-08mmHg at 25°C
• Melting Point: 170-172 °C
• Refractive Index: 1.575
• Boiling Point: 443.7 °C at 760 mmHg
• PKA: 4.18±0.20(Predicted)
• Flash Point: 222.1 °C
• PSA: 81.34000
• Density: 1.231 g/cm³
• LogP: 1.87110
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl 2-amino-7,8-dihydropyrido-[4,3-d]pyrimidine-6(5H)-carboxylate >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of YRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLIC ACID, 2-AMINO-7,8-DIHYDRO-, 1,1-DIMETHYLETHYL ESTER

There total 13 articles about YRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLIC ACID, 2-AMINO-7,8-DIHYDRO-, 1,1-DIMETHYLETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

t-butyl-3-[(dimethylamino)methylidene]-4-oxopiperidine-1-carboxylate (157327-41-8,1202645-17-7) + guanidine hydrogen carbonate (124-46-9,20734-13-8,100224-74-6,593-85-1,90332-86-8,3425-08-9) → 2-amino-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-carboxylic acid tert-butyl ester (869198-95-8)

Guidance literature:

With sodium acetate; In ethanol; at 115 ℃; for 1h; Microwave irradiation;

Reference yield: 55.0%

t-butyl-3-[(dimethylamino)methylidene]-4-oxopiperidine-1-carboxylate (157327-41-8,1202645-17-7) + guanidine carbonate → 2-amino-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-carboxylic acid tert-butyl ester (869198-95-8)

Guidance literature:

With sodium acetate; In ethanol; at 110 ℃; for 1h; Microwave irradiation;

Reference yield: 55.0%

t-butyl-3-[(dimethylamino)methylidene]-4-oxopiperidine-1-carboxylate (157327-41-8,1202645-17-7) → 2-amino-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-carboxylic acid tert-butyl ester (869198-95-8)

Guidance literature:

With guanidine hydrogen carbonate; sodium acetate; In methanol; for 17h; Reflux;

upstream raw materials:

t-butyl-3-[(dimethylamino)methylidene]-4-oxopiperidine-1-carboxylate

N-tert-butyloxycarbonylpiperidin-4-one

diguanidine carbonate

guanidinium carbonate

Downstream raw materials:

6-(tert-butoxycarbonyl)-2-iodo-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

3-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-yl)pyridin-2-amine

ethyl 6-(5'-chloro-3,5-dimethyl-2,4'-bipyridin-2'-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-ylcarbamate

6-(5'-chloro-3,5-dimethyl-2,4'-bipyridin-2'-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-amine