3-(4-Hydroxy-3-methoxy-phenyl)-6,7-dimethoxy-2-methyl-isoquinolinium; chloride

Base Information

Chemical Name:3-(4-Hydroxy-3-methoxy-phenyl)-6,7-dimethoxy-2-methyl-isoquinolinium; chloride
CAS No.:102349-20-2
Molecular Formula:C₁₉H₂₀NO₄*Cl
Molecular Weight:361.825
Hs Code.:

Synonyms:3-(4-Hydroxy-3-methoxy-phenyl)-6,7-dimethoxy-2-methyl-isoquinolinium; chloride

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Chemical Property of 3-(4-Hydroxy-3-methoxy-phenyl)-6,7-dimethoxy-2-methyl-isoquinolinium; chloride

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Technology Process of 3-(4-Hydroxy-3-methoxy-phenyl)-6,7-dimethoxy-2-methyl-isoquinolinium; chloride

There total 7 articles about 3-(4-Hydroxy-3-methoxy-phenyl)-6,7-dimethoxy-2-methyl-isoquinolinium; chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5653-42-9
3,4-dimethoxyhomophthalic anhydride

: 102349-20-2
3-(4-Hydroxy-3-methoxy-phenyl)-6,7-dimethoxy-2-methyl-isoquinolinium; chloride

Guidance literature:: Multi-step reaction with 6 steps

1: 65 percent / CHCl₃ / 0.5 h / 23 °C

2: 98 percent / acetic acid / 16 h / reflux

3: 50 percent / lead tetraacetate, cupric acetate / pyridine; benzene / 3 h / 80 °C

4: LiAlH₄ / tetrahydrofuran / 27 h / Heating

5: H₂ / Pd/C / acetic acid / 1 h / 23 °C

6: 2.) aq.NaCl / 1.) Pd/C / 1.) reflux, 24h, acetic acid

With lead(IV) acetate; lithium aluminium tetrahydride; hydrogen; copper diacetate; sodium chloride; palladium on activated charcoal; In tetrahydrofuran; pyridine; chloroform; acetic acid; benzene;
DOI:10.1016/S0040-4039(00)98752-5

Reference yield:

: 102349-14-4
[1-(4-Benzyloxy-3-methoxy-phenyl)-meth-(E)-ylidene]-methyl-amine

: 102349-20-2
3-(4-Hydroxy-3-methoxy-phenyl)-6,7-dimethoxy-2-methyl-isoquinolinium; chloride

Guidance literature:: Multi-step reaction with 6 steps

1: 65 percent / CHCl₃ / 0.5 h / 23 °C

2: 98 percent / acetic acid / 16 h / reflux

3: 50 percent / lead tetraacetate, cupric acetate / pyridine; benzene / 3 h / 80 °C

4: LiAlH₄ / tetrahydrofuran / 27 h / Heating

5: H₂ / Pd/C / acetic acid / 1 h / 23 °C

6: 2.) aq.NaCl / 1.) Pd/C / 1.) reflux, 24h, acetic acid

With lead(IV) acetate; lithium aluminium tetrahydride; hydrogen; copper diacetate; sodium chloride; palladium on activated charcoal; In tetrahydrofuran; pyridine; chloroform; acetic acid; benzene;
DOI:10.1016/S0040-4039(00)98752-5

Reference yield:

: (3R,4S)-3-(4-Benzyloxy-3-methoxy-phenyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydro-isoquinolin-4-ol

: 102349-20-2
3-(4-Hydroxy-3-methoxy-phenyl)-6,7-dimethoxy-2-methyl-isoquinolinium; chloride

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / Pd/C / acetic acid / 1 h / 23 °C

2: 2.) aq.NaCl / 1.) Pd/C / 1.) reflux, 24h, acetic acid

With hydrogen; sodium chloride; palladium on activated charcoal; In acetic acid;
DOI:10.1016/S0040-4039(00)98752-5