Acetic acid (3S,4R)-3-(4-benzyloxy-3-methoxy-phenyl)-6,7-dimethoxy-2-methyl-1-oxo-1,2,3,4-tetrahydro-isoquinolin-4-yl ester

Base Information

• Chemical Name: Acetic acid (3S,4R)-3-(4-benzyloxy-3-methoxy-phenyl)-6,7-dimethoxy-2-methyl-1-oxo-1,2,3,4-tetrahydro-isoquinolin-4-yl ester
• CAS No.: 102349-17-7
• Molecular Formula: C₂₈H₂₉NO₇
• Molecular Weight: 491.541
• Mol file: 102349-17-7.mol

Synonyms:Acetic acid (3S,4R)-3-(4-benzyloxy-3-methoxy-phenyl)-6,7-dimethoxy-2-methyl-1-oxo-1,2,3,4-tetrahydro-isoquinolin-4-yl ester

Chemical Property of Acetic acid (3S,4R)-3-(4-benzyloxy-3-methoxy-phenyl)-6,7-dimethoxy-2-methyl-1-oxo-1,2,3,4-tetrahydro-isoquinolin-4-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Acetic acid (3S,4R)-3-(4-benzyloxy-3-methoxy-phenyl)-6,7-dimethoxy-2-methyl-1-oxo-1,2,3,4-tetrahydro-isoquinolin-4-yl ester

There total 5 articles about Acetic acid (3S,4R)-3-(4-benzyloxy-3-methoxy-phenyl)-6,7-dimethoxy-2-methyl-1-oxo-1,2,3,4-tetrahydro-isoquinolin-4-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

(3R,4R)-3-(4-Benzyloxy-3-methoxy-phenyl)-6,7-dimethoxy-2-methyl-1-oxo-1,2,3,4-tetrahydro-isoquinoline-4-carboxylic acid (102349-15-5,102349-16-6) → 3-(4-Benzyloxy-3-methoxy-phenyl)-6,7-dimethoxy-2-methyl-2H-isoquinolin-1-one (102349-18-8) + Acetic acid (3S,4R)-3-(4-benzyloxy-3-methoxy-phenyl)-6,7-dimethoxy-2-methyl-1-oxo-1,2,3,4-tetrahydro-isoquinolin-4-yl ester (102349-17-7)

Guidance literature:

With lead(IV) acetate; copper diacetate; In pyridine; benzene; at 80 ℃; for 3h;

DOI:10.1016/S0040-4039(00)98752-5

Reference yield: 4.0%

copper diacetate (142-71-2) + lead(IV) tetraacetate (546-67-8) + (3R,4R)-3-(4-Benzyloxy-3-methoxy-phenyl)-6,7-dimethoxy-2-methyl-1-oxo-1,2,3,4-tetrahydro-isoquinoline-4-carboxylic acid (102349-15-5,102349-16-6) → 3-(4-Benzyloxy-3-methoxy-phenyl)-6,7-dimethoxy-2-methyl-2H-isoquinolin-1-one (102349-18-8) + Acetic acid (3S,4R)-3-(4-benzyloxy-3-methoxy-phenyl)-6,7-dimethoxy-2-methyl-1-oxo-1,2,3,4-tetrahydro-isoquinolin-4-yl ester (102349-17-7)

Guidance literature:

In pyridine; benzene; at 80 ℃; for 3h;

DOI:10.1016/S0040-4039(00)98752-5

Reference yield:

3,4-dimethoxyhomophthalic anhydride (5653-42-9) → Acetic acid (3S,4R)-3-(4-benzyloxy-3-methoxy-phenyl)-6,7-dimethoxy-2-methyl-1-oxo-1,2,3,4-tetrahydro-isoquinolin-4-yl ester (102349-17-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 65 percent / CHCl₃ / 0.5 h / 23 °C

2: 98 percent / acetic acid / 16 h / reflux

3: 50 percent / lead tetraacetate, cupric acetate / pyridine; benzene / 3 h / 80 °C

With lead(IV) acetate; copper diacetate; In pyridine; chloroform; acetic acid; benzene;

DOI:10.1016/S0040-4039(00)98752-5

upstream raw materials:

copper diacetate

lead(IV) tetraacetate

(3R,4R)-3-(4-Benzyloxy-3-methoxy-phenyl)-6,7-dimethoxy-2-methyl-1-oxo-1,2,3,4-tetrahydro-isoquinoline-4-carboxylic acid

3,4-dimethoxyhomophthalic anhydride

Downstream raw materials:

(3S,4R)-3-(4-Hydroxy-3-methoxy-phenyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydro-isoquinolin-4-ol

4-(4-Hydroxy-3-methoxy-phenyl)-6,7-dimethoxy-2-methyl-isoquinolinium; chloride

3-(4-Hydroxy-3-methoxy-phenyl)-6,7-dimethoxy-2-methyl-isoquinolinium; chloride