6-Morpholinopicolinonitrile

Base Information

• Chemical Name: 6-Morpholinopicolinonitrile
• CAS No.: 868755-53-7
• Molecular Formula: C₁₀H₁₁N₃O
• Molecular Weight: 189.217
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID00594499
• Wikidata: Q82489343
• Mol file: 868755-53-7.mol

Synonyms:6-morpholinopicolinonitrile;868755-53-7;6-morpholin-4-ylpyridine-2-carbonitrile;6-(morpholin-4-yl)pyridine-2-carbonitrile;SCHEMBL2814727;DTXSID00594499;WKDAOTSKEPJLCC-UHFFFAOYSA-N;MFCD08690244;AKOS006281661;MB06492;BS-24058;DB-350611;CS-0204966;EN300-140935;J-518933

Chemical Property of 6-Morpholinopicolinonitrile

Chemical Property:

• Vapor Pressure: 3.11E-06mmHg at 25°C
• Melting Point: 133 °C
• Refractive Index: 1.585
• Boiling Point: 388.3°C at 760 mmHg
• Flash Point: 188.6°C
• PSA: 49.15000
• Density: 1.23g/cm³
• LogP: 0.85488
• Storage Temp.: 2-8°C
• XLogP3: 1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 189.090211983
• Heavy Atom Count: 14
• Complexity: 229

Purity/Quality:

98%min ^*data from raw suppliers

6-morpholin-4-ylpyridine-2-carbonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COCCN1C2=CC=CC(=N2)C#N

Technology Process of 6-Morpholinopicolinonitrile

There total 6 articles about 6-Morpholinopicolinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.79%

morpholine (110-91-8,99108-56-2) + 6-fluoropyridine-2-carbonitrile (3939-15-9) → 6-(morpholin-4-yl)pyridine-2-carbonitrile (868755-53-7)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 6h;

Reference yield: 83.0%

sodium cyanide (143-33-9,25596-52-5) + copper(I) cyanide (544-92-3) + 4-(6-bromopyridin-2-yl)morpholine (332134-60-8) → 6-(morpholin-4-yl)pyridine-2-carbonitrile (868755-53-7)

Guidance literature:

sodium cyanide; copper(I) cyanide; 4-(6-bromopyridin-2-yl)morpholine; In N,N-dimethyl-formamide; at 150 ℃; for 4h;

With dipotassium hydrogenphosphate; In water; N,N-dimethyl-formamide; for 1h; Product distribution / selectivity;

Reference yield:

6-(morpholin-4-yl)pyridine-2-carboxamide (1061750-16-0) → 6-(morpholin-4-yl)pyridine-2-carbonitrile (868755-53-7)

Guidance literature:

With triethylamine; trifluoroacetic anhydride; In dichloromethane; at 0 - 20 ℃;

DOI:10.1021/jm800851u

upstream raw materials:

sodium cyanide

copper(I) cyanide

4-(6-bromopyridin-2-yl)morpholine

6-(morpholin-4-yl)pyridine-2-carboxamide