2-Bromo-6-morpholinopyridine

Base Information

• Chemical Name: 2-Bromo-6-morpholinopyridine
• CAS No.: 332134-60-8
• Molecular Formula: C9H11BrN2O
• Molecular Weight: 243.10000
• Hs Code.: 2934999090
• European Community (EC) Number: 692-186-0
• DSSTox Substance ID: DTXSID70428191
• Nikkaji Number: J1.811.651K
• Wikidata: Q82240987
• Mol file: 332134-60-8.mol

Synonyms:2-Bromo-6-morpholinopyridine;332134-60-8;4-(6-bromopyridin-2-yl)morpholine;4-(6-bromopyrid-2-yl)morpholine;Morpholine, 4-(6-bromo-2-pyridinyl)-;MFCD07772824;SCHEMBL5329;DTXSID70428191;RCGFRLCJCFDVOQ-UHFFFAOYSA-N;4-(6-Bromo-2-pyridinyl)morpholine;2-Bromo-6-(morpholin-4-yl)pyridine;4-(6-Bromo-pyridin-2-yl)morpholine;4-(6-bromo-pyridin-2-yl)-morpholine;AKOS013153650;AB42258;AM86867;AS-5655;CS-W004142;DS-1141;SY006462;FT-0744146;4-(6-bromopyridin-2-yl)morpholine, AldrichCPR;A22056;J-513611;F0001-0982

Chemical Property of 2-Bromo-6-morpholinopyridine

Chemical Property:

• Vapor Pressure: 9.79E-06mmHg at 25°C
• Melting Point: 50oC
• Boiling Point: 372.2oC at 760 mmHg
• PKA: 1.42±0.20(Predicted)
• Flash Point: 178.9oC
• PSA: 25.36000
• Density: 1.499g/cm3
• LogP: 1.74570
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 242.00548
• Heavy Atom Count: 13
• Complexity: 162

Purity/Quality:

97% ^*data from raw suppliers

4-(6-Bromopyridin-2-yl)morpholine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COCCN1C2=NC(=CC=C2)Br

Technology Process of 2-Bromo-6-morpholinopyridine

There total 1 articles about 2-Bromo-6-morpholinopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

pyrrolidin-3-ol (40499-83-0) + 2,6-Dibromopyridine (626-05-1) + 1,8-diazbicyclo[5.4.0]-7-undecene → 2-bromo-6-(3-hydroxypyrrolidine-1-yl)pyridine (332135-62-3,1379445-24-5,1264034-44-7) + 4-(6-bromopyridin-2-yl)morpholine (332134-60-8)

Guidance literature:

In tetrahydrofuran; hexane; ethyl acetate;

Reference yield: 83.0%

sodium cyanide (143-33-9,25596-52-5) + copper(I) cyanide (544-92-3) + 4-(6-bromopyridin-2-yl)morpholine (332134-60-8) → 6-(morpholin-4-yl)pyridine-2-carbonitrile (868755-53-7)

Guidance literature:

sodium cyanide; copper(I) cyanide; 4-(6-bromopyridin-2-yl)morpholine; In N,N-dimethyl-formamide; at 150 ℃; for 4h;

With dipotassium hydrogenphosphate; In water; N,N-dimethyl-formamide; for 1h; Product distribution / selectivity;

Reference yield: 80.0%

3-phenyl-2H-thiete 1,1-dioxide (25903-17-7) + 4-(6-bromopyridin-2-yl)morpholine (332134-60-8) → 4-(6-Morpholinopyridin-2-yl)-3-phenyl-2H-thiete 1,1-dioxide

Guidance literature:

With palladium diacetate; potassium carbonate; tricyclohexylphosphine; Trimethylacetic acid; In toluene; at 120 ℃; for 16h; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.orglett.8b01961

upstream raw materials:

pyrrolidin-3-ol

2,6-Dibromopyridine

Downstream raw materials:

6-(morpholin-4-yl)pyridine-2-carbonitrile