ethyl 2,2-dimethyl-6-(4-methyl-N-(3-phenylprop-2-ynyl)phenylsulfonamido)hex-4-ynoate

Base Information

• Chemical Name: ethyl 2,2-dimethyl-6-(4-methyl-N-(3-phenylprop-2-ynyl)phenylsulfonamido)hex-4-ynoate
• CAS No.: 1219596-62-9
• Molecular Formula: C₂₆H₂₉NO₄S
• Molecular Weight: 451.587
• Mol file: 1219596-62-9.mol

Synonyms:ethyl 2,2-dimethyl-6-(4-methyl-N-(3-phenylprop-2-ynyl)phenylsulfonamido)hex-4-ynoate

Chemical Property of ethyl 2,2-dimethyl-6-(4-methyl-N-(3-phenylprop-2-ynyl)phenylsulfonamido)hex-4-ynoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2,2-dimethyl-6-(4-methyl-N-(3-phenylprop-2-ynyl)phenylsulfonamido)hex-4-ynoate

There total 1 articles about ethyl 2,2-dimethyl-6-(4-methyl-N-(3-phenylprop-2-ynyl)phenylsulfonamido)hex-4-ynoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

ethyl 6-bromo-2,2-dimethylhex-4-ynoate (1140383-31-8) + 4-methyl-N-(3-phenylprop-2-yn-1-yl)benzenesulfonamide (305837-95-0) → ethyl 2,2-dimethyl-6-(4-methyl-N-(3-phenylprop-2-ynyl)phenylsulfonamido)hex-4-ynoate (1219596-62-9)

Guidance literature:

4-methyl-N-(3-phenylprop-2-yn-1-yl)benzenesulfonamide; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 0.5h; Inert atmosphere;

ethyl 6-bromo-2,2-dimethylhex-4-ynoate; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/ol100318f

Reference yield: 94.0%

ethyl 2,2-dimethyl-6-(4-methyl-N-(3-phenylprop-2-ynyl)phenylsulfonamido)hex-4-ynoate (1219596-62-9) + N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) → N-methoxy-N,2,2-trimethyl-6-(4-methyl-N-(3-phenylprop-2-ynyl)phenylsulfonamido)hex-4-ynamide (1219596-64-1)

Guidance literature:

With isopropylmagnesium chloride; In tetrahydrofuran; at -20 - 20 ℃; Inert atmosphere;

DOI:10.1021/ol100318f

upstream raw materials:

ethyl 6-bromo-2,2-dimethylhex-4-ynoate

4-methyl-N-(3-phenylprop-2-yn-1-yl)benzenesulfonamide

Downstream raw materials:

N-methoxy-N,2,2-trimethyl-6-(4-methyl-N-(3-phenylprop-2-ynyl)phenylsulfonamido)hex-4-ynamide