diisopropyl 1,1-difluoro-5-(6-(p-toluenesulfonyloxy)-1-hexanesulfure)pentylphosphonate

Base Information

• Chemical Name: diisopropyl 1,1-difluoro-5-(6-(p-toluenesulfonyloxy)-1-hexanesulfure)pentylphosphonate
• CAS No.: 1363335-99-2
• Molecular Formula: C₂₄H₄₁F₂O₆PS₂
• Molecular Weight: 558.689
• Mol file: 1363335-99-2.mol

Synonyms:diisopropyl 1,1-difluoro-5-(6-(p-toluenesulfonyloxy)-1-hexanesulfure)pentylphosphonate

Chemical Property of diisopropyl 1,1-difluoro-5-(6-(p-toluenesulfonyloxy)-1-hexanesulfure)pentylphosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diisopropyl 1,1-difluoro-5-(6-(p-toluenesulfonyloxy)-1-hexanesulfure)pentylphosphonate

There total 3 articles about diisopropyl 1,1-difluoro-5-(6-(p-toluenesulfonyloxy)-1-hexanesulfure)pentylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

diisopropyl 1,1-difluoro-5-(6-hydroxy-1-hexanesulfure)pentylphosphonate (1363335-97-0) + p-toluenesulfonyl chloride (98-59-9) → diisopropyl 1,1-difluoro-5-(6-(p-toluenesulfonyloxy)-1-hexanesulfure)pentylphosphonate (1363335-99-2)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 15h;

DOI:10.1021/jm201694y

Reference yield:

6-mercapto-1-hexanol (1633-78-9) → diisopropyl 1,1-difluoro-5-(6-(p-toluenesulfonyloxy)-1-hexanesulfure)pentylphosphonate (1363335-99-2)

Guidance literature:

Multi-step reaction with 2 steps

1: N,N,N',N'-tetramethylguanidine / acetonitrile / 15 h / 20 °C

2: triethylamine / dichloromethane / 15 h / 20 °C

With triethylamine; N,N,N',N'-tetramethylguanidine; In dichloromethane; acetonitrile;

DOI:10.1021/jm201694y

Reference yield:

diisopropyl 1,1-difluoro-5-(p-toluenesulfonyloxy)pentylphosphonate (1050534-41-2) → diisopropyl 1,1-difluoro-5-(6-(p-toluenesulfonyloxy)-1-hexanesulfure)pentylphosphonate (1363335-99-2)

Guidance literature:

Multi-step reaction with 2 steps

1: N,N,N',N'-tetramethylguanidine / acetonitrile / 15 h / 20 °C

2: triethylamine / dichloromethane / 15 h / 20 °C

With triethylamine; N,N,N',N'-tetramethylguanidine; In dichloromethane; acetonitrile;

DOI:10.1021/jm201694y

upstream raw materials:

diisopropyl 1,1-difluoro-5-(p-toluenesulfonyloxy)pentylphosphonate

diisopropyl 1,1-difluoro-5-(6-hydroxy-1-hexanesulfure)pentylphosphonate

p-toluenesulfonyl chloride

6-mercapto-1-hexanol