diisopropyl 1,1-difluoro-5-(p-toluenesulfonyloxy)pentylphosphonate

Base Information

• Chemical Name: diisopropyl 1,1-difluoro-5-(p-toluenesulfonyloxy)pentylphosphonate
• CAS No.: 1050534-41-2
• Molecular Formula: C₁₈H₂₉F₂O₆PS
• Molecular Weight: 442.461
• Mol file: 1050534-41-2.mol

Synonyms:diisopropyl 1,1-difluoro-5-(p-toluenesulfonyloxy)pentylphosphonate

Chemical Property of diisopropyl 1,1-difluoro-5-(p-toluenesulfonyloxy)pentylphosphonate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of diisopropyl 1,1-difluoro-5-(p-toluenesulfonyloxy)pentylphosphonate

There total 1 articles about diisopropyl 1,1-difluoro-5-(p-toluenesulfonyloxy)pentylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

p-toluenesulfonyl chloride (98-59-9) + diisopropyl 1,1-difluoro-5-hydroxypentylphosphonate (792960-04-4) → diisopropyl 1,1-difluoro-5-(p-toluenesulfonyloxy)pentylphosphonate (1050534-41-2)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1021/ol801443s DOI:10.1039/b912724k

Reference yield: 81.0%

diisopropyl 1,1-difluoro-5-(p-toluenesulfonyloxy)pentylphosphonate (1050534-41-2) + N-3-benzoylthymine (4330-20-5) → diisopropyl 5-(3-benzoyl-5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-1,1-difluoropentylphosphonate (1050534-49-0)

Guidance literature:

With N,N,N',N'-tetramethylguanidine; In dimethyl sulfoxide; at 20 ℃; for 15h; regioselective reaction; Inert atmosphere;

DOI:10.1021/ol801443s

Reference yield:

diisopropyl 1,1-difluoro-5-(p-toluenesulfonyloxy)pentylphosphonate (1050534-41-2) + 3-N-benzoyluracil (2775-87-3) → C22H29F2N2O6P

Guidance literature:

With N,N,N',N'-tetramethylguanidine; In dimethyl sulfoxide; at 20 ℃; for 15h;

DOI:10.1021/jm201694y

upstream raw materials:

p-toluenesulfonyl chloride

diisopropyl 1,1-difluoro-5-hydroxypentylphosphonate

Downstream raw materials:

diisopropyl 5-(3-benzoyl-5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-1,1-difluoropentylphosphonate

diisopropyl 1,1-difluoro-5-(6-(p-toluenesulfonyloxy)-1-hexanesulfure)pentylphosphonate