5-{3-[Methoxy-bis-(4-methoxy-phenyl)-methyl]-phenoxy}-4-oxo-pentanoic acid (2R,3S,5R)-2-hydroxymethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

Base Information

Chemical Name:5-{3-[Methoxy-bis-(4-methoxy-phenyl)-methyl]-phenoxy}-4-oxo-pentanoic acid (2R,3S,5R)-2-hydroxymethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester
CAS No.:178313-79-6
Molecular Formula:C₃₇H₄₀N₂O₁₁
Molecular Weight:688.731
Hs Code.:

5-{3-[Methoxy-bis-(4-methoxy-phenyl)-methyl]-phenoxy}-4-oxo-pentanoic acid (2R,3S,5R)-2-hydroxymethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

Synonyms:5-{3-[Methoxy-bis-(4-methoxy-phenyl)-methyl]-phenoxy}-4-oxo-pentanoic acid (2R,3S,5R)-2-hydroxymethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

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Chemical Property of 5-{3-[Methoxy-bis-(4-methoxy-phenyl)-methyl]-phenoxy}-4-oxo-pentanoic acid (2R,3S,5R)-2-hydroxymethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

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Technology Process of 5-{3-[Methoxy-bis-(4-methoxy-phenyl)-methyl]-phenoxy}-4-oxo-pentanoic acid (2R,3S,5R)-2-hydroxymethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

There total 5 articles about 5-{3-[Methoxy-bis-(4-methoxy-phenyl)-methyl]-phenoxy}-4-oxo-pentanoic acid (2R,3S,5R)-2-hydroxymethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 40615-39-2
5'-O-(4-4'-dimethoxytrityl)thymidine

: 178313-79-6
5-{3-[Methoxy-bis-(4-methoxy-phenyl)-methyl]-phenoxy}-4-oxo-pentanoic acid (2R,3S,5R)-2-hydroxymethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 4-dimethylaminopyridine, pyridine / 0.5 h

2: 80percent AcOH

3: glacial AcOH / CH₂Cl₂

With pyridine; dmap; acetic acid; In dichloromethane;
DOI:10.1016/0040-4020(96)00337-7

Reference yield:

: 169141-00-8
C₅₂H₅₀O₁₃

: 178313-79-6
5-{3-[Methoxy-bis-(4-methoxy-phenyl)-methyl]-phenoxy}-4-oxo-pentanoic acid (2R,3S,5R)-2-hydroxymethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 4-dimethylaminopyridine, pyridine / 0.5 h

2: 80percent AcOH

3: glacial AcOH / CH₂Cl₂

With pyridine; dmap; acetic acid; In dichloromethane;
DOI:10.1016/0040-4020(96)00337-7

Reference yield:

: 169140-99-2
5-<3-(bis-4-methoxyphenyl)-hydroxymethyl>-phenoxy-levulinic acid

: 178313-79-6
5-{3-[Methoxy-bis-(4-methoxy-phenyl)-methyl]-phenoxy}-4-oxo-pentanoic acid (2R,3S,5R)-2-hydroxymethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1: N,N'-dicylohexylcarbodiimide / dioxane

2: 4-dimethylaminopyridine, pyridine / 0.5 h

3: 80percent AcOH

4: glacial AcOH / CH₂Cl₂

With pyridine; dmap; acetic acid; dicyclohexyl-carbodiimide; In 1,4-dioxane; dichloromethane;
DOI:10.1016/0040-4020(96)00337-7