5-FLUORO-1-TRIISOPROPYLSILANYL-1H-PYRROLO[2,3-B]PYRIDINE

Base Information

• Chemical Name: 5-FLUORO-1-TRIISOPROPYLSILANYL-1H-PYRROLO[2,3-B]PYRIDINE
• CAS No.: 868387-37-5
• Molecular Formula: C₁₆H₂₅FN₂Si
• Molecular Weight: 292.472
• Hs Code.: 2933990090
• Mol file: 868387-37-5.mol

Synonyms:5-FLUORO-1-TRIISOPROPYLSILANYL-1H-PYRROLO[2,3-B]PYRIDINE;1H-Pyrrolo[2,3-b]pyridine, 5-fluoro-1-[tris(1-methylethyl)silyl]-

Chemical Property of 5-FLUORO-1-TRIISOPROPYLSILANYL-1H-PYRROLO[2,3-B]PYRIDINE

Chemical Property:

• Vapor Pressure: 0.000833mmHg at 25°C
• Refractive Index: 1.514
• Boiling Point: 305.2°C at 760 mmHg
• Flash Point: 138.4°C
• PSA: 17.82000
• Density: 1.02g/cm³
• LogP: 5.19900

Purity/Quality:

97% ^*data from raw suppliers

5-Fluoro-1-triisopropylsilanyl-1h-pyrrolo[2,3-b]pyridine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-FLUORO-1-TRIISOPROPYLSILANYL-1H-PYRROLO[2,3-B]PYRIDINE

There total 4 articles about 5-FLUORO-1-TRIISOPROPYLSILANYL-1H-PYRROLO[2,3-B]PYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

5-bromo-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine (858116-66-2) → 5‐fluoro-1-triisopropylsilylpyrrolo[2,3‐b]pyridine (868387-37-5)

Guidance literature:

5-bromo-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

With N-fluorobis(benzenesulfon)imide; In tetrahydrofuran; at -78 - 20 ℃; for 2h;

Reference yield: 50.2%

5-bromo-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine (858116-66-2) → 1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine (1093759-49-9) + 5‐fluoro-1-triisopropylsilylpyrrolo[2,3‐b]pyridine (868387-37-5)

Guidance literature:

5-bromo-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 1.16667h;

With N-fluorobis(benzenesulfon)imide; In tetrahydrofuran; at -78 ℃; for 2h;

Reference yield:

5-fluoro-1H-pyrrolo[2,3‐b]pyridine (866319-00-8) + triisopropylsilyl chloride (13154-24-0) → 5‐fluoro-1-triisopropylsilylpyrrolo[2,3‐b]pyridine (868387-37-5)

Guidance literature:

5-fluoro-1H-pyrrolo[2,3‐b]pyridine; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.5h;

triisopropylsilyl chloride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 2h;

upstream raw materials:

5-bromo-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine

triisopropylsilyl chloride

5-bromo-1H-pyrrolo[2,3-b]pyridine

5-fluoro-1H-pyrrolo[2,3‐b]pyridine

Downstream raw materials:

5-fluoro-1H-pyrrolo[2,3‐b]pyridine

5-fluoro-3-iodo-1H-pyrrolo[2,3-b]pyridine

5-fluoro-1H-pyrrolo[2,3-b]pyridine-4-carbaldehyde

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