1093759-49-9

Usage

Chemical compound

A chemical compound used as a building block in organic synthesis and medicinal chemistry.

Substituted pyridine derivative

It is a derivative of pyridine with a triisopropylsilyl group attached to the nitrogen atom.

Versatile intermediate

Known for its ability to serve as a versatile intermediate in the synthesis of various pharmaceuticals and agrochemicals.

Unique structure and reactivity

Its unique structure and reactivity make it a valuable tool for creating complex organic molecules.

Development of potential drug candidates

Utilized in the development of potential drug candidates and other bioactive compounds.

Protection for the nitrogen atom

The triisopropylsilyl group provides protection for the nitrogen atom, allowing for selective chemical transformations.

Enhanced stability

Enhances the compound's stability during chemical reactions due to the protective nature of the triisopropylsilyl group.

Upstream product

• 13154-24-0 triisopropylsilyl chloride 
• 858116-66-2 5-bromo-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine 
• 183208-35-7 5-bromo-1H-pyrrolo[2,3-b]pyridine 
• 640735-24-6 4-bromo-1-[tris(propan-2-yl)silyl]-1H-pyrrolo[2,3-b]pyridine 
• 348640-06-2 4-bromo-7-azaindole 
• 918525-02-7 3-bromo-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine 
• 74420-15-8 3-bromo-1H-pyrrolo[2,3-b]pyridine 
• 271-63-6 7-Azaindole 

Relevant academic research and scientific papers

Au-Catalyzed Cross-Coupling of Arenes via Double C-H Activation

The first methodology for Au(I/III)-catalyzed oxidative cross-coupling of arenes via double C-H activation has been developed. The reaction is fully selective for the cross-coupling between electron-rich hetero-/carbocyclic arenes and electron-poor arenes bearing relatively acidic C-H bonds. The inherently high cross-selectivity of the system obviates the need for directing groups or a large excess of one of the coupling partners.

A closer look at the bromine-lithium exchange with tert-butyllithium in an aryl sulfonamide synthesis

A practical protocol for the one-pot synthesis of various aryl sulfonamides, notably of pyridine-core-substituted 7-azaindolyl sulfonamides, is described. A key step is the well-known bromine-lithium exchange reaction of an aryl bromide with tert-butyllithium (t-BuLi). Differing from the common practice to use 2 or more equiv of organolithium, the exact amount of t-BuLi needed for a sufficient exchange reaction is determined for each aryl bromide in a GC-MS-assisted experiment.

AZAINDOLES USEFUL AS INHIBITORS OF ROCK AND OTHER PROTEIN KINASES

The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.