2-[(1-benzyloxycarbonylamino-3-methyl-butyl)-hydroxy-phosphinoylmethyl]-pent-4-ynoic acid ethyl ester

Base Information

Chemical Name:2-[(1-benzyloxycarbonylamino-3-methyl-butyl)-hydroxy-phosphinoylmethyl]-pent-4-ynoic acid ethyl ester
CAS No.:1019330-49-4
Molecular Formula:C₂₁H₃₀NO₆P
Molecular Weight:423.446
Hs Code.:

Synonyms:2-[(1-benzyloxycarbonylamino-3-methyl-butyl)-hydroxy-phosphinoylmethyl]-pent-4-ynoic acid ethyl ester

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Chemical Property of 2-[(1-benzyloxycarbonylamino-3-methyl-butyl)-hydroxy-phosphinoylmethyl]-pent-4-ynoic acid ethyl ester

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Technology Process of 2-[(1-benzyloxycarbonylamino-3-methyl-butyl)-hydroxy-phosphinoylmethyl]-pent-4-ynoic acid ethyl ester

There total 1 articles about 2-[(1-benzyloxycarbonylamino-3-methyl-butyl)-hydroxy-phosphinoylmethyl]-pent-4-ynoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 54109-54-5
ethyl α-propargyl acrylate

: 109638-99-5
(+/-)-1-benzyloxycarbonylamino-3-methylbutylphosphonous acid

: 1019330-49-4
2-[(1-benzyloxycarbonylamino-3-methyl-butyl)-hydroxy-phosphinoylmethyl]-pent-4-ynoic acid ethyl ester

Guidance literature:: ethyl α-propargyl acrylate; With 1,1,1,3,3,3-hexamethyl-disilazane; at 110 ℃; for 1h;

(+/-)-1-benzyloxycarbonylamino-3-methylbutylphosphonous acid; at 110 ℃; for 4h;

With ethanol; at 70 ℃; Further stages.;
DOI:10.1021/jm701275z

Reference yield: 83.0%

: 1019330-49-4
2-[(1-benzyloxycarbonylamino-3-methyl-butyl)-hydroxy-phosphinoylmethyl]-pent-4-ynoic acid ethyl ester

: 932-90-1
Benzaldoxime

: 1019330-50-7
3-[(1-benzyloxycarbonylamino-3-methyl-butyl)-hydroxy-phosphinoyl]-2-(3-phenyl-isoxazol-5-ylmethyl)-propionic acid ethyl ester

Guidance literature:: Benzaldoxime; With pyridine; N-chloro-succinimide; In chloroform; at 45 ℃; for 3h;

2-[(1-benzyloxycarbonylamino-3-methyl-butyl)-hydroxy-phosphinoylmethyl]-pent-4-ynoic acid ethyl ester; With triethylamine; In chloroform; at 45 ℃; for 72h; Further stages.;
DOI:10.1021/jm701275z