ETHYL 2-METHYLENE-4-PENTYNOATE

Base Information

• Chemical Name: ETHYL 2-METHYLENE-4-PENTYNOATE
• CAS No.: 54109-54-5
• Molecular Formula: C8H10O2
• Molecular Weight: 138.16
• Hs Code.: 2916190090
• Mol file: 54109-54-5.mol

Synonyms:ETHYL 2-METHYLENE-4-PENTYNOATE

Chemical Property of ETHYL 2-METHYLENE-4-PENTYNOATE

Chemical Property:

• Vapor Pressure: 0.0888mmHg at 25°C
• Refractive Index: 1.448
• Boiling Point: 224.9°C at 760 mmHg
• Flash Point: 60°C
• PSA: 26.30000
• Density: 0.967g/cm³
• LogP: 1.12900

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL 2-METHYLENE-4-PENTYNOATE

There total 5 articles about ETHYL 2-METHYLENE-4-PENTYNOATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + ethyl(2-benzoylpent-4-ynoate) (92190-57-3) → ethyl α-propargyl acrylate (54109-54-5)

Guidance literature:

With potassium carbonate; In tetrahydrofuran; at 65 ℃; for 4h;

Reference yield: 78.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + ethyl 3-oxo-3-phenylpropionate (94-02-0) + propargyl bromide (106-96-7) → ethyl α-propargyl acrylate (54109-54-5)

Guidance literature:

ethyl 3-oxo-3-phenylpropionate; propargyl bromide; With potassium carbonate; sodium iodide; In toluene; at 20 ℃; for 24h;

formaldehyd; With potassium carbonate; In tetrahydrofuran; at 40 ℃; for 216h; Further stages.;

DOI:10.1002/ejoc.200700197

Reference yield: 60.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + (1-Ethoxycarbonyl-3-butinyl)phosphonsaeure-diethylester (26199-74-6) → ethyl α-propargyl acrylate (54109-54-5)

Guidance literature:

With potassium carbonate;

DOI:10.1016/S0040-4039(01)81756-1

upstream raw materials:

formaldehyd

(1-Ethoxycarbonyl-3-butinyl)phosphonsaeure-diethylester

ethyl(2-benzoylpent-4-ynoate)

ethyl 3-oxo-3-phenylpropionate

Downstream raw materials:

2-(2-Oxo-cyclohexylmethyl)-pent-4-ynoic acid ethyl ester

2-(1-Methyl-2,6-dioxo-cyclohexylmethyl)-pent-4-ynoic acid ethyl ester

(1R)-1-{[(benzyloxy)carbonyl]amino}-2-phenylethyl[2-(ethoxycarbonyl)pent-4-ynyl]phosphinic acid