1-(2-{4-[2-(4-ethanesulfonyl-phenyl)-6-methoxy-naphthalen-1-yloxy]-phenoxy}-ethyl)-piperidine

Base Information

Chemical Name:1-(2-{4-[2-(4-ethanesulfonyl-phenyl)-6-methoxy-naphthalen-1-yloxy]-phenoxy}-ethyl)-piperidine
CAS No.:648904-77-2
Molecular Formula:C₃₂H₃₅NO₅S
Molecular Weight:545.7
Hs Code.:

Synonyms:1-(2-{4-[2-(4-ethanesulfonyl-phenyl)-6-methoxy-naphthalen-1-yloxy]-phenoxy}-ethyl)-piperidine

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Chemical Property of 1-(2-{4-[2-(4-ethanesulfonyl-phenyl)-6-methoxy-naphthalen-1-yloxy]-phenoxy}-ethyl)-piperidine

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Technology Process of 1-(2-{4-[2-(4-ethanesulfonyl-phenyl)-6-methoxy-naphthalen-1-yloxy]-phenoxy}-ethyl)-piperidine

There total 7 articles about 1-(2-{4-[2-(4-ethanesulfonyl-phenyl)-6-methoxy-naphthalen-1-yloxy]-phenoxy}-ethyl)-piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 648904-46-5
trifluoromethanesulfonic acid 6-methoxy-1-[4-(2-piperidin-1-ylethoxy)phenoxy]naphthalen-2-yl ester

: 352530-24-6
4-(ethylsulfonyl)phenylboronic acid

: 648904-77-2
1-(2-{4-[2-(4-ethanesulfonyl-phenyl)-6-methoxy-naphthalen-1-yloxy]-phenoxy}-ethyl)-piperidine

Guidance literature:: With cesium fluoride; tricyclohexylphosphine; palladium diacetate;
DOI:10.1016/j.bmcl.2007.04.044

Reference yield:

: 648904-47-6
2-(benzyloxy)-1-bromo-6-methoxynaphthalene

: 648904-77-2
1-(2-{4-[2-(4-ethanesulfonyl-phenyl)-6-methoxy-naphthalen-1-yloxy]-phenoxy}-ethyl)-piperidine

Guidance literature:: Multi-step reaction with 4 steps

1: 30 percent / copper triflate

2: NH₄HCO₂ / Pd(OH)2

3: PCy₃; CsF / Pd(OAc)2

With ammonium formate; copper(I) triflate; cesium fluoride; tricyclohexylphosphine; palladium diacetate; palladium dihydroxide; 1: Ullman coupling / 4: Suzuki coupling;
DOI:10.1016/j.bmcl.2007.04.044

Reference yield:

: 648904-49-8
6-methoxy-1-[4-(2-piperidin-1-ylethoxy)phenoxy]naphthalene-2-ol

: 648904-77-2
1-(2-{4-[2-(4-ethanesulfonyl-phenyl)-6-methoxy-naphthalen-1-yloxy]-phenoxy}-ethyl)-piperidine

Guidance literature:: Multi-step reaction with 2 steps

1: PCy₃; CsF / Pd(OAc)2

With cesium fluoride; tricyclohexylphosphine; palladium diacetate; 2: Suzuki coupling;
DOI:10.1016/j.bmcl.2007.04.044