(S)-N-(1-(4-(benzyloxy)phenyl)-3-hydroxypropan-2-yl)-N-methylamine

Base Information

• Chemical Name: (S)-N-(1-(4-(benzyloxy)phenyl)-3-hydroxypropan-2-yl)-N-methylamine
• CAS No.: 442128-85-0
• Molecular Formula: C₁₇H₂₁NO₂
• Molecular Weight: 271.359
• Mol file: 442128-85-0.mol

Synonyms:(S)-N-(1-(4-(benzyloxy)phenyl)-3-hydroxypropan-2-yl)-N-methylamine

Chemical Property of (S)-N-(1-(4-(benzyloxy)phenyl)-3-hydroxypropan-2-yl)-N-methylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-N-(1-(4-(benzyloxy)phenyl)-3-hydroxypropan-2-yl)-N-methylamine

There total 7 articles about (S)-N-(1-(4-(benzyloxy)phenyl)-3-hydroxypropan-2-yl)-N-methylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

methyl (2S)-3-(4-benzyloxyphenyl)-2-ethoxycarbonylaminopropionate (442128-78-1) → (S)-N-(1-(4-(benzyloxy)phenyl)-3-hydroxypropan-2-yl)-N-methylamine (442128-85-0)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; Heating;

DOI:10.1016/S0040-4039(02)00296-4

Reference yield: 88.0%

L-(N-methoxycarbonyl)(O-benzyl)tyrosine methyl ester → (S)-N-(1-(4-(benzyloxy)phenyl)-3-hydroxypropan-2-yl)-N-methylamine (442128-85-0)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 3h; Reflux;

Reference yield:

L-tyrosine methyl ester HCl (3417-91-2) → (S)-N-(1-(4-(benzyloxy)phenyl)-3-hydroxypropan-2-yl)-N-methylamine (442128-85-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 84 percent / K₂CO₃ / dioxane; H₂O / 2 h / 0 °C

2: 88 percent / K₂CO₃ / acetone / 12 h / 20 °C

3: 92 percent / lithium aluminum hydride / tetrahydrofuran / 4 h / Heating

With lithium aluminium tetrahydride; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; water; acetone;

DOI:10.3987/com-03-s(p)14

upstream raw materials:

methyl (2S)-3-(4-benzyloxyphenyl)-2-ethoxycarbonylaminopropionate

L-tyrosine methyl ester HCl

(S)-3-(4-hydroxyphenyl)-2-[(ethoxycarbonyl)amino]-1-propanoic acid methyl ester

L-tyrosine

Downstream raw materials:

1,1-dimethylethyl N-[(1S)-2-hydroxy-1-{[4-(phenylmethoxy)phenyl]methyl}ethyl]-N-methylcarbamate

(S)-4-(3-hydroxy-2-(methylamino)propyl)phenol

methyl N-[(2S)-3-(4-benzyloxyphenyl)-2-(tert-butoxycarbonylmethylamino)propyl]aminoacetate

methyl N-[(2S)-3-(4-benzyloxyphenyl)-2-methylaminopropyl]aminoacetate