Methyl 4-O-benzyl-6-O-tert-butyldiphenylsilyl-2,3-di-O-isopropylidene-α-D-mannopyranoside

Base Information

Chemical Name:Methyl 4-O-benzyl-6-O-tert-butyldiphenylsilyl-2,3-di-O-isopropylidene-α-D-mannopyranoside
CAS No.:150161-11-8
Molecular Formula:C₃₃H₄₂O₆Si
Molecular Weight:562.778
Hs Code.:

Synonyms:Methyl 4-O-benzyl-6-O-tert-butyldiphenylsilyl-2,3-di-O-isopropylidene-α-D-mannopyranoside

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Chemical Property of Methyl 4-O-benzyl-6-O-tert-butyldiphenylsilyl-2,3-di-O-isopropylidene-α-D-mannopyranoside

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Technology Process of Methyl 4-O-benzyl-6-O-tert-butyldiphenylsilyl-2,3-di-O-isopropylidene-α-D-mannopyranoside

There total 3 articles about Methyl 4-O-benzyl-6-O-tert-butyldiphenylsilyl-2,3-di-O-isopropylidene-α-D-mannopyranoside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 100-39-0
benzyl bromide

: 131089-35-5
methyl 6-O-tert-butyldiphenylsilyl-2,3-O-isopropylidene-α-D-mannopyranoside

: 150161-11-8
Methyl 4-O-benzyl-6-O-tert-butyldiphenylsilyl-2,3-di-O-isopropylidene-α-D-mannopyranoside

Guidance literature:: With N,N,N,N,N,N-hexamethylphosphoric triamide; tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; at 23 ℃; for 2h;
DOI:10.1002/anie.200353478

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 150161-11-8
Methyl 4-O-benzyl-6-O-tert-butyldiphenylsilyl-2,3-di-O-isopropylidene-α-D-mannopyranoside

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / imidazole / dimethylformamide / 5 h / Ambient temperature

2: 84 percent / NaH / dimethylformamide / 1.) 0 deg C, 30 min, 2.) o deg C to room temperature

With 1H-imidazole; sodium hydride; In N,N-dimethyl-formamide;
DOI:10.1021/jo9806097

Reference yield:

: 63167-69-1
methyl 2,3-O-isopropylidene-α-D-mannopyranoside

: 150161-11-8
Methyl 4-O-benzyl-6-O-tert-butyldiphenylsilyl-2,3-di-O-isopropylidene-α-D-mannopyranoside

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / imidazole / dimethylformamide / 5 h / Ambient temperature

2: 84 percent / NaH / dimethylformamide / 1.) 0 deg C, 30 min, 2.) o deg C to room temperature

With 1H-imidazole; sodium hydride; In N,N-dimethyl-formamide;
DOI:10.1021/jo9806097