(S)-2-<3-(allyloxy)phenyl>-3-benzyloxy-1-<(tetrahydropyran-2-yl)oxy>propane

Base Information

Chemical Name:(S)-2-<3-(allyloxy)phenyl>-3-benzyloxy-1-<(tetrahydropyran-2-yl)oxy>propane
CAS No.:183799-81-7
Molecular Formula:C₂₄H₃₀O₄
Molecular Weight:382.5
Hs Code.:

Synonyms:(S)-2-<3-(allyloxy)phenyl>-3-benzyloxy-1-<(tetrahydropyran-2-yl)oxy>propane

Suppliers and Price of (S)-2-<3-(allyloxy)phenyl>-3-benzyloxy-1-<(tetrahydropyran-2-yl)oxy>propane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-<3-(allyloxy)phenyl>-3-benzyloxy-1-<(tetrahydropyran-2-yl)oxy>propane

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Technology Process of (S)-2-<3-(allyloxy)phenyl>-3-benzyloxy-1-<(tetrahydropyran-2-yl)oxy>propane

There total 14 articles about (S)-2-<3-(allyloxy)phenyl>-3-benzyloxy-1-<(tetrahydropyran-2-yl)oxy>propane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 100-39-0
benzyl bromide

: 183799-79-3
(S)-2-<3-(allyloxy)phenyl>-3-<(tetrahydropyran-2-yl)oxy>propan-1-ol

: 183799-81-7
(S)-2-<3-(allyloxy)phenyl>-3-benzyloxy-1-<(tetrahydropyran-2-yl)oxy>propane

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; Ambient temperature;
DOI:10.1016/S0040-4039(00)61382-5

Reference yield:

: 22446-38-4
ethyl 3-hydroxyphenylacetate

: 183799-81-7
(S)-2-<3-(allyloxy)phenyl>-3-benzyloxy-1-<(tetrahydropyran-2-yl)oxy>propane

Guidance literature:: Multi-step reaction with 7 steps

1: 96 percent / K₂CO₃ / 4 h / 55 °C

2: 90 percent / LDA / tetrahydrofuran / 0.5 h / -78 °C

3: 63 percent / DIBALH / CH₂Cl₂ / 0 °C / to room temperature

4: 3A molecular sieves / PPL / 24 h / 0 °C

5: p-TSA / CH₂Cl₂ / Ambient temperature

6: KOH / methanol / Ambient temperature

7: 98 percent / NaH / dimethylformamide / Ambient temperature

With potassium hydroxide; 3 A molecular sieve; sodium hydride; diisobutylaluminium hydride; potassium carbonate; toluene-4-sulfonic acid; lithium diisopropyl amide; PPL; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)61382-5

Reference yield:

: 621-37-4
m-hydroxyphenylacetic acid

: 183799-81-7
(S)-2-<3-(allyloxy)phenyl>-3-benzyloxy-1-<(tetrahydropyran-2-yl)oxy>propane

Guidance literature:: Multi-step reaction with 8 steps

1: 94 percent / H₂SO₄ / Heating

2: 96 percent / K₂CO₃ / 4 h / 55 °C

3: 90 percent / LDA / tetrahydrofuran / 0.5 h / -78 °C

4: 63 percent / DIBALH / CH₂Cl₂ / 0 °C / to room temperature

5: 3A molecular sieves / PPL / 24 h / 0 °C

6: p-TSA / CH₂Cl₂ / Ambient temperature

7: KOH / methanol / Ambient temperature

8: 98 percent / NaH / dimethylformamide / Ambient temperature

With potassium hydroxide; 3 A molecular sieve; sulfuric acid; sodium hydride; diisobutylaluminium hydride; potassium carbonate; toluene-4-sulfonic acid; lithium diisopropyl amide; PPL; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)61382-5