propane-1-sulfonic acid {3-[5-(6-chloro-pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide

Base Information

• Chemical Name: propane-1-sulfonic acid {3-[5-(6-chloro-pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide
• CAS No.: 1254565-63-3
• Molecular Formula: C₂₂H₁₇ClF₂N₄O₃S
• Molecular Weight: 490.918
• Mol file: 1254565-63-3.mol

Synonyms:propane-1-sulfonic acid {3-[5-(6-chloro-pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide

Chemical Property of propane-1-sulfonic acid {3-[5-(6-chloro-pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of propane-1-sulfonic acid {3-[5-(6-chloro-pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide

There total 6 articles about propane-1-sulfonic acid {3-[5-(6-chloro-pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-[3-(5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluoro-phenyl]propane-1-sulfonamide (918504-27-5) + 6-chloropyridin-3-ylboronic acid (444120-91-6) → propane-1-sulfonic acid {3-[5-(6-chloro-pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide (1254565-63-3)

Guidance literature:

With potassium carbonate; bis-triphenylphosphine-palladium(II) chloride; In acetonitrile; at 160 ℃; for 0.0833333h; Microwave irradiation;

Reference yield:

2,6-difluoro-3-(propane-1-sulfonylamino)benzoic acid (1103234-56-5) → propane-1-sulfonic acid {3-[5-(6-chloro-pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide (1254565-63-3)

Guidance literature:

Multi-step reaction with 3 steps

1: thionyl chloride / toluene / 3 h / Reflux

2: aluminum (III) chloride / dichloromethane / 5 - 20 °C / Inert atmosphere

3: potassium carbonate / bis-triphenylphosphine-palladium(II) chloride / acetonitrile / 0.08 h / 160 °C / Microwave irradiation

With aluminum (III) chloride; thionyl chloride; potassium carbonate; bis-triphenylphosphine-palladium(II) chloride; In dichloromethane; toluene; acetonitrile;

Reference yield:

3-amino-2,6-difluoro-benzoic acid benzyl ester (918523-44-1) → propane-1-sulfonic acid {3-[5-(6-chloro-pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide (1254565-63-3)

Guidance literature:

Multi-step reaction with 5 steps

1: pyridine / dichloromethane / 20 °C

2: hydrogen / 20% palladium hydroxide-activated charcoal / methanol / 0.25 h / 760.05 Torr

3: thionyl chloride / toluene / 3 h / Reflux

4: aluminum (III) chloride / dichloromethane / 5 - 20 °C / Inert atmosphere

5: potassium carbonate / bis-triphenylphosphine-palladium(II) chloride / acetonitrile / 0.08 h / 160 °C / Microwave irradiation

With pyridine; aluminum (III) chloride; thionyl chloride; hydrogen; potassium carbonate; bis-triphenylphosphine-palladium(II) chloride; 20% palladium hydroxide-activated charcoal; In methanol; dichloromethane; toluene; acetonitrile;

upstream raw materials:

N-[3-(5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluoro-phenyl]propane-1-sulfonamide

6-chloropyridin-3-ylboronic acid

2,6-difluoro-3-(propylsulfonamido)benzoyl chloride

3-amino-2,6-difluoro-benzoic acid benzyl ester