(1α,2α,6α,7α)-4-benzyl-4-azatricyclo[5.2.1.0^2,6]dec-8-ene-3,5-dione

Base Information

• Chemical Name: (1α,2α,6α,7α)-4-benzyl-4-azatricyclo[5.2.1.0^2,6]dec-8-ene-3,5-dione
• CAS No.: 75715-21-8
• Molecular Formula: C₁₆H₁₅NO₂
• Molecular Weight: 253.301
• Mol file: 75715-21-8.mol

Synonyms:(1α,2α,6α,7α)-4-benzyl-4-azatricyclo[5.2.1.0^2,6]dec-8-ene-3,5-dione

Chemical Property of (1α,2α,6α,7α)-4-benzyl-4-azatricyclo[5.2.1.0^2,6]dec-8-ene-3,5-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1α,2α,6α,7α)-4-benzyl-4-azatricyclo[5.2.1.0^2,6]dec-8-ene-3,5-dione

There total 8 articles about (1α,2α,6α,7α)-4-benzyl-4-azatricyclo[5.2.1.0^2,6]dec-8-ene-3,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

C17H13NO2 (1251910-89-0) + cyclopenta-1,3-diene (542-92-7,25568-84-7,7313-32-8) → (1α,2α,6α,7α)-4-benzyl-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione (75715-21-8)

Guidance literature:

at 20 ℃; for 0.0333333h;

DOI:10.1055/s-0036-1558970

Reference yield: 99.0%

benzylamine (100-46-9) + 3,6-endomethylene-1,2,3,6-tetrahydrophthalic anhydride (129-64-6) → (1α,2α,6α,7α)-4-benzyl-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione (75715-21-8)

Guidance literature:

In acetic acid; for 5h; Inert atmosphere; Reflux;

DOI:10.1002/ejoc.201300889

Reference yield: 81.0%

benzyl bromide (100-39-0) + (1R,2S,6R,7S)-4-azatricyclo[5.2.1.0(2,6)]dec-8-ene-3,5-dione (6265-30-1) → (1α,2α,6α,7α)-4-benzyl-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione (75715-21-8)

Guidance literature:

(1R,2S,6R,7S)-4-azatricyclo[5.2.1.0(2,6)]dec-8-ene-3,5-dione; With potassium carbonate; for 1h; Milling;

benzyl bromide; In N,N-dimethyl-formamide; for 1h; Milling;

DOI:10.3762/bjoc.13.169

upstream raw materials:

benzylamine

3,6-endomethylene-1,2,3,6-tetrahydrophthalic anhydride

endo-3-(N-benzylcarbamoyl)bicyclo[2.2.1]hept-5-ene-endo-2-carboxylic acid

benzyl chloride

Downstream raw materials:

2-benzyl-5c,6c-epoxy-(3ac,7ac)-hexahydro-4r,7c-methano-isoindole-1,3-dione

2-benzyl-1,3,r-3a,4,7,c-7a-hexahydro-t-4,t-7-methanoisoindole