(S)-2-N-[N'-(2-fluorobenzyl)prolyl]aminobenzophenone hydrochloride

Base Information

Chemical Name:(S)-2-N-[N'-(2-fluorobenzyl)prolyl]aminobenzophenone hydrochloride
CAS No.:1204821-30-6
Molecular Formula:C₂₅H₂₃FN₂O₂*ClH
Molecular Weight:438.929
Hs Code.:

Synonyms:(S)-2-N-[N'-(2-fluorobenzyl)prolyl]aminobenzophenone hydrochloride

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Chemical Property of (S)-2-N-[N'-(2-fluorobenzyl)prolyl]aminobenzophenone hydrochloride

Chemical Property:

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Technology Process of (S)-2-N-[N'-(2-fluorobenzyl)prolyl]aminobenzophenone hydrochloride

There total 11 articles about (S)-2-N-[N'-(2-fluorobenzyl)prolyl]aminobenzophenone hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.7%

: 446-48-0
o-fluorobenzyl bromide

: 1609121-29-0
L-proline-2-aminobenzophenone amide hydrochloride

: 1204821-30-6
(S)-2-N-[N'-(2-fluorobenzyl)prolyl]aminobenzophenone hydrochloride

Guidance literature:: o-fluorobenzyl bromide; L-proline-2-aminobenzophenone amide hydrochloride; With potassium carbonate; In acetonitrile; at 0 - 70 ℃; for 8h;

With hydrogenchloride; In ethyl acetate; for 1h; Cooling with ice;

In acetone; for 3h; Cooling with ice;
DOI:10.1016/j.tetlet.2017.05.007

Reference yield:

: 288-32-4
1H-imidazole

: C₂₈H₂₆FN₃NiO₄

: 1204821-30-6
(S)-2-N-[N'-(2-fluorobenzyl)prolyl]aminobenzophenone hydrochloride

: 114717-14-5,68068-70-2
(S)-2-amino-3-(1H-imidazol-1-yl)propionic acid

Guidance literature:: C₂₈H₂₆FN₃NiO₄; With acetic anhydride; sodium carbonate; In acetonitrile; at 25 - 70 ℃;

1H-imidazole; With sodium hydroxide; In acetonitrile; at 50 ℃; for 1.5h;

With hydrogenchloride; water; In ethanol;
DOI:10.1016/j.tetasy.2010.10.015

Reference yield:

: C₂₈H₂₆FN₃NiO₄

: 141-43-5
ethanolamine

: 1204821-30-6
(S)-2-N-[N'-(2-fluorobenzyl)prolyl]aminobenzophenone hydrochloride

: (S)-2-amino-3-(2-hydroxyethylamino)propionic acid hydrochloride

Guidance literature:: C₂₈H₂₆FN₃NiO₄; With acetic anhydride; sodium carbonate; In acetonitrile; at 25 - 70 ℃;

ethanolamine; With sodium hydroxide; In acetonitrile; at 50 ℃; for 0.333333h;

With hydrogenchloride; water; In ethanol;
DOI:10.1016/j.tetasy.2010.10.015