(E)-3-(2-fluoro-4-(((2'-methyl-[1,1'-biphenyl]-3-yl)methyl)amino)phenyl)acrylic acid

Base Information

Chemical Name:(E)-3-(2-fluoro-4-(((2'-methyl-[1,1'-biphenyl]-3-yl)methyl)amino)phenyl)acrylic acid
CAS No.:1390641-92-5
Molecular Formula:C₂₃H₂₀FNO₂
Molecular Weight:361.416
Hs Code.:

Synonyms:(E)-3-(2-fluoro-4-(((2'-methyl-[1,1'-biphenyl]-3-yl)methyl)amino)phenyl)acrylic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-3-(2-fluoro-4-(((2'-methyl-[1,1'-biphenyl]-3-yl)methyl)amino)phenyl)acrylic acid

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Technology Process of (E)-3-(2-fluoro-4-(((2'-methyl-[1,1'-biphenyl]-3-yl)methyl)amino)phenyl)acrylic acid

There total 2 articles about (E)-3-(2-fluoro-4-(((2'-methyl-[1,1'-biphenyl]-3-yl)methyl)amino)phenyl)acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 371764-26-0
2'-methyl-(1,1'-biphenyl)-3-carbaldehyde

: 1390641-83-4
(E)-3-(4-amino-2-fluorophenyl)acrylic Acid

: 1390641-92-5
(E)-3-(2-fluoro-4-(((2'-methyl-[1,1'-biphenyl]-3-yl)methyl)amino)phenyl)acrylic acid

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane; at 20 ℃;
DOI:10.1021/jm3002026

Reference yield:

: 865137-76-4
ethyl (2E)-3-(4-amino-2-fluorophenyl)prop-2-enoate

: 1390641-92-5
(E)-3-(2-fluoro-4-(((2'-methyl-[1,1'-biphenyl]-3-yl)methyl)amino)phenyl)acrylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water / 20 °C

2: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 20 °C

With lithium hydroxide monohydrate; sodium tris(acetoxy)borohydride; acetic acid; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/jm3002026