tert-butyl 4-[3-(N,N-dimethylcarbamoyloxy)phenylcarbamoyl]-4-(2-methoxyethoxy)piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-[3-(N,N-dimethylcarbamoyloxy)phenylcarbamoyl]-4-(2-methoxyethoxy)piperidine-1-carboxylate
CAS No.:1192189-62-0
Molecular Formula:C₂₄H₃₇N₃O₇
Molecular Weight:479.574
Hs Code.:

Synonyms:tert-butyl 4-[3-(N,N-dimethylcarbamoyloxy)phenylcarbamoyl]-4-(2-methoxyethoxy)piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-[3-(N,N-dimethylcarbamoyloxy)phenylcarbamoyl]-4-(2-methoxyethoxy)piperidine-1-carboxylate

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Technology Process of tert-butyl 4-[3-(N,N-dimethylcarbamoyloxy)phenylcarbamoyl]-4-(2-methoxyethoxy)piperidine-1-carboxylate

There total 4 articles about tert-butyl 4-[3-(N,N-dimethylcarbamoyloxy)phenylcarbamoyl]-4-(2-methoxyethoxy)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1192189-61-9
1-(tert-butoxycarbonyl)-4-(2-methoxyethoxy)piperidine-4-carboxylic acid

: 19962-04-0
Dimethylcarbaminsaeure-3-aminophenylester

: 1192189-62-0
tert-butyl 4-[3-(N,N-dimethylcarbamoyloxy)phenylcarbamoyl]-4-(2-methoxyethoxy)piperidine-1-carboxylate

Guidance literature:: 1-(tert-butoxycarbonyl)-4-(2-methoxyethoxy)piperidine-4-carboxylic acid; With pyridine; oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; for 0.5h; Inert atmosphere;

Dimethylcarbaminsaeure-3-aminophenylester; In dichloromethane; for 18h; Inert atmosphere;
DOI:10.1021/ml500367g

Reference yield:

: C₁₅H₂₆ClNO₅

: 19962-04-0
Dimethylcarbaminsaeure-3-aminophenylester

: 1192189-62-0
tert-butyl 4-[3-(N,N-dimethylcarbamoyloxy)phenylcarbamoyl]-4-(2-methoxyethoxy)piperidine-1-carboxylate

Guidance literature:: With pyridine; In 1,2-dichloro-ethane; for 18h;

Reference yield:

: 142851-03-4
1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate

: 1192189-62-0
tert-butyl 4-[3-(N,N-dimethylcarbamoyloxy)phenylcarbamoyl]-4-(2-methoxyethoxy)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 1.13 h / -78 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: lithium hydroxide; water / ethanol / 18 h / 80 °C / Inert atmosphere

3.1: pyridine; oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.5 h / Inert atmosphere

3.2: 18 h / Inert atmosphere

With pyridine; oxalyl dichloride; water; N,N-dimethyl-formamide; lithium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/ml500367g