N-tert-butoxycarbonyl-N'-phenyl-N'-pyrazinecarbonylhydrazide

Base Information

• Chemical Name: N-tert-butoxycarbonyl-N'-phenyl-N'-pyrazinecarbonylhydrazide
• CAS No.: 1338369-87-1
• Molecular Formula: C₁₆H₁₈N₄O₃
• Molecular Weight: 314.344
• Mol file: 1338369-87-1.mol

Synonyms:N-tert-butoxycarbonyl-N'-phenyl-N'-pyrazinecarbonylhydrazide

Chemical Property of N-tert-butoxycarbonyl-N'-phenyl-N'-pyrazinecarbonylhydrazide

Chemical Property:

Purity/Quality:

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Technology Process of N-tert-butoxycarbonyl-N'-phenyl-N'-pyrazinecarbonylhydrazide

There total 2 articles about N-tert-butoxycarbonyl-N'-phenyl-N'-pyrazinecarbonylhydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

pyrazinoyl chloride (19847-10-0) + tert-butyl 2-phenylhydrazine-1-carboxylate (42116-43-8) → N-tert-butoxycarbonyl-N'-phenyl-N'-pyrazinecarbonylhydrazide (1338369-87-1)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃;

DOI:10.1055/s-0030-1260082

Reference yield:

2-pyrazylcarboxylic acid (98-97-5) → N-tert-butoxycarbonyl-N'-phenyl-N'-pyrazinecarbonylhydrazide (1338369-87-1)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / toluene / 1 h / Reflux; Inert atmosphere

2: triethylamine / dichloromethane / 20 °C

With thionyl chloride; triethylamine; In dichloromethane; toluene;

DOI:10.1055/s-0030-1260082

Reference yield: 61.0%

N-tert-butoxycarbonyl-N'-phenyl-N'-pyrazinecarbonylhydrazide (1338369-87-1) → N-phenyl-N-pyrazine-2-carbohydrazide (1338369-55-3)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 6h; Inert atmosphere;

DOI:10.1055/s-0030-1260082

upstream raw materials:

2-pyrazylcarboxylic acid

pyrazinoyl chloride

tert-butyl 2-phenylhydrazine-1-carboxylate

Downstream raw materials:

N-phenyl-N-pyrazine-2-carbohydrazide

N-(phenyl)pyrazine-2-carboxamide

Refernces