Technology Process of 6-((5-(3-(difluoromethoxy)phenyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)methyl)quinoline
There total 9 articles about 6-((5-(3-(difluoromethoxy)phenyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)methyl)quinoline which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
potassium carbonate;
tetrakis(triphenylphosphine) palladium(0);
In
1,4-dioxane; water;
at 20 ℃;
for 12h;
Inert atmosphere;
Reflux;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium carbonate / ethanol / 12 h / 0 - 20 °C
2.1: hydrogenchloride; tin(ll) chloride / water / 2 h / 20 °C
2.2: pH 8 / Cooling with ice
3.1: sodium nitrite; sulfuric acid / water; acetic acid / 0.5 h / 5 - 20 °C
3.2: pH 8 / Cooling with ice
4.1: potassium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 12 h / 20 °C / Inert atmosphere; Reflux
With
hydrogenchloride; sulfuric acid; sodium carbonate; potassium carbonate; tin(ll) chloride; sodium nitrite;
tetrakis(triphenylphosphine) palladium(0);
In
1,4-dioxane; ethanol; water; acetic acid;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: sulfuric acid; 4-nitro-phenol / 48 h / 135 °C
1.2: 0 °C / pH 3 - 5
2.1: thionyl chloride / 12 h / 0 - 65 °C
3.1: water; ammonia / methanol / 12 h / 45 °C
4.1: triethylamine; trifluoroacetic anhydride / chloroform / 1.5 h / 10 °C
4.2: pH 7
5.1: hydrogen / Raney-Ni / ammonia; methanol / 16 h / 20 °C / 760.05 Torr
6.1: sodium carbonate / ethanol / 12 h / 0 - 20 °C
7.1: hydrogenchloride; tin(ll) chloride / water / 2 h / 20 °C
7.2: pH 8 / Cooling with ice
8.1: sodium nitrite; sulfuric acid / water; acetic acid / 0.5 h / 5 - 20 °C
8.2: pH 8 / Cooling with ice
9.1: potassium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 12 h / 20 °C / Inert atmosphere; Reflux
With
hydrogenchloride; thionyl chloride; 4-nitro-phenol; sulfuric acid; ammonia; water; hydrogen; sodium carbonate; potassium carbonate; triethylamine; trifluoroacetic anhydride; tin(ll) chloride; sodium nitrite;
tetrakis(triphenylphosphine) palladium(0);
In
1,4-dioxane; methanol; ethanol; chloroform; ammonia; water; acetic acid;
