2-[3-bromo-5-(1,1-dimethylethyl)-2-(2-propen-1-yloxy)phenyl]-2-propanol

Base Information

• Chemical Name: 2-[3-bromo-5-(1,1-dimethylethyl)-2-(2-propen-1-yloxy)phenyl]-2-propanol
• CAS No.: 866933-38-2
• Molecular Formula: C₁₆H₂₃BrO₂
• Molecular Weight: 327.261
• Mol file: 866933-38-2.mol

Synonyms:2-[3-bromo-5-(1,1-dimethylethyl)-2-(2-propen-1-yloxy)phenyl]-2-propanol

Chemical Property of 2-[3-bromo-5-(1,1-dimethylethyl)-2-(2-propen-1-yloxy)phenyl]-2-propanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[3-bromo-5-(1,1-dimethylethyl)-2-(2-propen-1-yloxy)phenyl]-2-propanol

There total 2 articles about 2-[3-bromo-5-(1,1-dimethylethyl)-2-(2-propen-1-yloxy)phenyl]-2-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

1,3-dibromo-5-(1,1-dimethylethyl)-2-(2-propen-1-yloxy)benzene (104207-39-8) + acetone (67-64-1) → 2-[3-bromo-5-(1,1-dimethylethyl)-2-(2-propen-1-yloxy)phenyl]-2-propanol (866933-38-2)

Guidance literature:

1,3-dibromo-5-(1,1-dimethylethyl)-2-(2-propen-1-yloxy)benzene; With n-butyllithium; In diethyl ether; at -78 ℃;

acetone; In diethyl ether; at -78 ℃;

DOI:10.1016/j.jcat.2005.06.021

Reference yield:

2,6-dibromo-4-tert-butylphenol (98-22-6) → 2-[3-bromo-5-(1,1-dimethylethyl)-2-(2-propen-1-yloxy)phenyl]-2-propanol (866933-38-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 95 percent / nBu₄NOH / CH₂Cl₂; H₂O / 24 h / 20 °C

2.1: n-BuLi / diethyl ether / 1 h / -78 °C

2.2: 65 percent / diethyl ether / -78 - 20 °C

With n-butyllithium; tetra(n-butyl)ammonium hydroxide; In diethyl ether; dichloromethane; water;

DOI:10.1021/jo052113c

Reference yield: 55.0%

2-[3-bromo-5-(1,1-dimethylethyl)-2-(2-propen-1-yloxy)phenyl]-2-propanol (866933-38-2) + triethylene glycol di-(p-toluenesulfonate) (19249-03-7) → C38H56Br2O6

Guidance literature:

With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 48h;

DOI:10.1021/jo052113c

upstream raw materials:

1,3-dibromo-5-(1,1-dimethylethyl)-2-(2-propen-1-yloxy)benzene

acetone

2,6-dibromo-4-tert-butylphenol

Downstream raw materials:

C₄₃H₅₆Br₂O₅