1-(3,4-difluorophenyl)-N,N,N-trimethylmethanaminium trifluoromethanesulfonate

Base Information

Chemical Name:1-(3,4-difluorophenyl)-N,N,N-trimethylmethanaminium trifluoromethanesulfonate
CAS No.:1416982-17-6
Molecular Formula:CF₃O₃S*C₁₀H₁₄F₂N
Molecular Weight:335.295
Hs Code.:

Synonyms:1-(3,4-difluorophenyl)-N,N,N-trimethylmethanaminium trifluoromethanesulfonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(3,4-difluorophenyl)-N,N,N-trimethylmethanaminium trifluoromethanesulfonate

Chemical Property:

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Technology Process of 1-(3,4-difluorophenyl)-N,N,N-trimethylmethanaminium trifluoromethanesulfonate

There total 2 articles about 1-(3,4-difluorophenyl)-N,N,N-trimethylmethanaminium trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1416982-27-8
N,N-dimethyl-3,4-difluorobenzylamine

: 333-27-7
methyl trifluoromethanesulfonate

: 1416982-17-6
1-(3,4-difluorophenyl)-N,N,N-trimethylmethanaminium trifluoromethanesulfonate

Guidance literature:: In diethyl ether; at 0 ℃; for 0.25h;
DOI:10.1021/ja3089422

Reference yield:

: 34036-07-2
3,4 difluorobenzaldehyde

: 1416982-17-6
1-(3,4-difluorophenyl)-N,N,N-trimethylmethanaminium trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine; titanium(IV) isopropylate / ethanol / 12 h / 25 °C / Inert atmosphere

1.2: 10 h / 25 °C / Inert atmosphere

2.1: diethyl ether / 0.5 h / 0 - 20 °C / Inert atmosphere

With titanium(IV) isopropylate; triethylamine; In diethyl ether; ethanol;
DOI:10.1021/acs.joc.1c01984

Reference yield: 96.0%

: 1416982-17-6
1-(3,4-difluorophenyl)-N,N,N-trimethylmethanaminium trifluoromethanesulfonate

: 5720-05-8
4-methylphenylboronic acid

: 1416981-87-7
1,2-difluoro-4-(4-methylbenzyl)benzene

Guidance literature:: With bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; potassium phosphate; cyclohexyldiphenylphosphine; In 1,4-dioxane; at 40 ℃; for 24h; Reagent/catalyst; Inert atmosphere; Glovebox;
DOI:10.1021/ja3089422