(2R,S_S)-1,1-Dichloro-1-fluoro-3-<(4-methylphenyl)sulfinyl>propan-2-ol

Base Information

• Chemical Name: (2R,S_S)-1,1-Dichloro-1-fluoro-3-<(4-methylphenyl)sulfinyl>propan-2-ol
• CAS No.: 132164-18-2
• Molecular Formula: C₁₀H₁₁Cl₂FO₂S
• Molecular Weight: 285.167
• Mol file: 132164-18-2.mol

Synonyms:(2R,S_S)-1,1-Dichloro-1-fluoro-3-<(4-methylphenyl)sulfinyl>propan-2-ol

Chemical Property of (2R,S_S)-1,1-Dichloro-1-fluoro-3-<(4-methylphenyl)sulfinyl>propan-2-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,S_S)-1,1-Dichloro-1-fluoro-3-<(4-methylphenyl)sulfinyl>propan-2-ol

There total 1 articles about (2R,S_S)-1,1-Dichloro-1-fluoro-3-<(4-methylphenyl)sulfinyl>propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2,2-dichloro-2-fluoroacetate (383-61-9) + (S)-methyl p-tolyl sulfoxide (5056-07-5) → (2R,SS)-1,1-Dichloro-1-fluoro-3-<(4-methylphenyl)sulfinyl>propan-2-ol (132164-18-2) + (S)-1,1-Dichloro-1-fluoro-3-((S)-toluene-4-sulfinyl)-propan-2-ol (133343-51-8)

Guidance literature:

Yield given. Multistep reaction. Yields of byproduct given;

Reference yield: 98.0%

(2R,SS)-1,1-Dichloro-1-fluoro-3-<(4-methylphenyl)sulfinyl>propan-2-ol (132164-18-2) + Cinnamyl bromide (4392-24-9) → 1-[(S)-(R)-3,3-Dichloro-3-fluoro-2-((E)-3-phenyl-allyloxy)-propane-1-sulfinyl]-4-methyl-benzene

Guidance literature:

With sodium hydroxide; trioctylethyl-ammonium bromide; In dichloromethane; Ambient temperature;

DOI:10.1016/S0040-4020(01)85741-0

Reference yield: 90.0%

4-bromo-trans-crotonic acid ethyl ester (37746-78-4) + (2R,SS)-1,1-Dichloro-1-fluoro-3-<(4-methylphenyl)sulfinyl>propan-2-ol (132164-18-2) → (E)-4-[(R)-2,2-Dichloro-2-fluoro-1-((S)-toluene-4-sulfinylmethyl)-ethoxy]-but-2-enoic acid ethyl ester (153107-66-5)

Guidance literature:

With sodium hydroxide; trioctylethyl-ammonium bromide; In dichloromethane; water; for 2h; Ambient temperature;

DOI:10.1016/S0040-4020(01)85741-0

upstream raw materials:

ethyl 2,2-dichloro-2-fluoroacetate

(S)-methyl p-tolyl sulfoxide

Downstream raw materials:

1-[(S)-(R)-3,3-Dichloro-3-fluoro-2-(3-methyl-but-2-enyloxy)-propane-1-sulfinyl]-4-methyl-benzene

(E)-4-[(R)-2,2-Dichloro-2-fluoro-1-((S)-toluene-4-sulfinylmethyl)-ethoxy]-but-2-enoic acid ethyl ester

(R)-1,1-dichloro-1-fluoro-3-<(4-methylphenyl)thio>propan-2-ol

1-((S)-(R)-2-Allyloxy-3,3-dichloro-3-fluoro-propane-1-sulfinyl)-4-methyl-benzene