2-(4-methoxy-1-naphthoyl)benzoic acid

Base Information

• Chemical Name: 2-(4-methoxy-1-naphthoyl)benzoic acid
• CAS No.: 342904-40-9
• Molecular Formula: C₁₉H₁₄O₄
• Molecular Weight: 306.318
• Mol file: 342904-40-9.mol

Synonyms:2-(4-methoxy-1-naphthoyl)benzoic acid

Chemical Property of 2-(4-methoxy-1-naphthoyl)benzoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-methoxy-1-naphthoyl)benzoic acid

There total 12 articles about 2-(4-methoxy-1-naphthoyl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

3-(4-methoxynaphthalen-1-yl)isobenzofuran-1(3H)-one (60049-53-8) → 2-(4-methoxy-1-naphthoyl)benzoic acid (342904-40-9)

Guidance literature:

With pyridine; potassium permanganate; potassium hydroxide; In water; for 5h; Reflux;

DOI:10.1021/acs.jmedchem.9b00632

Reference yield:

phthalic anhydride (85-44-9) + 1-Methoxynaphthalene (2216-69-5) → 2-(4-methoxy-1-naphthoyl)benzoic acid (342904-40-9)

Guidance literature:

With aluminium trichloride;

Reference yield:

2-bromo-N-(2-hydroxy-1,1-dimethylethyl)benzamide (54596-21-3) → 2-(4-methoxy-1-naphthoyl)benzoic acid (342904-40-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: thionyl chloride

1.2: 6 h / 20 °C

2.1: n-butyllithium / n-heptane; diethyl ether / 1 h / -78 °C / Inert atmosphere

2.2: 20 °C

3.1: potassium permanganate; potassium hydroxide; pyridine / water / 5 h / Reflux

With pyridine; potassium permanganate; n-butyllithium; thionyl chloride; potassium hydroxide; In diethyl ether; n-heptane; water;

DOI:10.1021/acs.jmedchem.9b00632

upstream raw materials:

phthalic anhydride

1-Methoxynaphthalene

Phthaloyl dichloride

aluminium trichloride

Downstream raw materials:

3-Methyl-3-(4-methoxyl-1-naphthyl)phthalid

benzene-1,2-dicarboxylic acid

1-Methoxynaphthalene

3-(4-methoxynaphthalen-1-yl)isobenzofuran-1(3H)-one