[(S)-(4-Chloro-phenyl)-phenyl-methyl]-(2,2-dimethoxy-ethyl)-amine

Base Information

• Chemical Name: [(S)-(4-Chloro-phenyl)-phenyl-methyl]-(2,2-dimethoxy-ethyl)-amine
• CAS No.: 292066-77-4
• Molecular Formula: C₁₇H₂₀ClNO₂
• Molecular Weight: 305.804
• Mol file: 292066-77-4.mol

Synonyms:[(S)-(4-Chloro-phenyl)-phenyl-methyl]-(2,2-dimethoxy-ethyl)-amine

Chemical Property of [(S)-(4-Chloro-phenyl)-phenyl-methyl]-(2,2-dimethoxy-ethyl)-amine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of [(S)-(4-Chloro-phenyl)-phenyl-methyl]-(2,2-dimethoxy-ethyl)-amine

There total 1 articles about [(S)-(4-Chloro-phenyl)-phenyl-methyl]-(2,2-dimethoxy-ethyl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

1-bromo-2,2-dimethoxyethane (7252-83-7) + (S)-4-chloro-α-phenyl-benzenemethanamine (163837-32-9) → [(S)-(4-Chloro-phenyl)-phenyl-methyl]-(2,2-dimethoxy-ethyl)-amine (292066-77-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 120 ℃;

DOI:10.1021/jo991937p

Reference yield: 79.0%

n-butyl formate (592-84-7) + [(S)-(4-Chloro-phenyl)-phenyl-methyl]-(2,2-dimethoxy-ethyl)-amine (292066-77-4) → N-[(4-chloro-phenyl)-phenyl-methyl]-N-(2,2-dimethoxy-ethyl)-formamide (292066-78-5)

Guidance literature:

Heating;

DOI:10.1021/jo991937p

Reference yield:

[(S)-(4-Chloro-phenyl)-phenyl-methyl]-(2,2-dimethoxy-ethyl)-amine (292066-77-4) → 1-[(4-chloro-phenyl)-phenyl-methyl]-1H-imidazole

Guidance literature:

Multi-step reaction with 2 steps

1: 79 percent / Heating

2: 71 percent / AcONH₄ / acetic acid / 3 h / Heating

With ammonium acetate; In acetic acid; 1: Formylation / 2: Cyclization;

DOI:10.1021/jo991937p

upstream raw materials:

1-bromo-2,2-dimethoxyethane

(S)-4-chloro-α-phenyl-benzenemethanamine

Downstream raw materials:

N-[(4-chloro-phenyl)-phenyl-methyl]-N-(2,2-dimethoxy-ethyl)-formamide