5-t-butyldiphenylsilyloxymethyl-5'-O-t-butyldiphenylsilyluridine 2',3'-bisxanthate

Base Information

Chemical Name:5-t-butyldiphenylsilyloxymethyl-5'-O-t-butyldiphenylsilyluridine 2',3'-bisxanthate
CAS No.:917482-59-8
Molecular Formula:C₄₆H₅₄N₂O₇S₄Si₂
Molecular Weight:931.379
Hs Code.:

Synonyms:5-t-butyldiphenylsilyloxymethyl-5'-O-t-butyldiphenylsilyluridine 2',3'-bisxanthate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-t-butyldiphenylsilyloxymethyl-5'-O-t-butyldiphenylsilyluridine 2',3'-bisxanthate

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Technology Process of 5-t-butyldiphenylsilyloxymethyl-5'-O-t-butyldiphenylsilyluridine 2',3'-bisxanthate

There total 10 articles about 5-t-butyldiphenylsilyloxymethyl-5'-O-t-butyldiphenylsilyluridine 2',3'-bisxanthate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 917482-58-7
5-t-butyldiphenylsilyloxymethyl-5'-O-t-butyldiphenylsilyluridine

: 75-15-0,12122-00-8
carbon disulfide

: 74-88-4
methyl iodide

: 917482-59-8
5-t-butyldiphenylsilyloxymethyl-5'-O-t-butyldiphenylsilyluridine 2',3'-bisxanthate

Guidance literature:: 5-t-butyldiphenylsilyloxymethyl-5'-O-t-butyldiphenylsilyluridine; carbon disulfide; With sodium hydroxide; In water; dimethyl sulfoxide; at 20 ℃; for 0.333333h;

methyl iodide; In water; dimethyl sulfoxide; for 1.5h;
DOI:10.1016/j.tetlet.2006.09.083

Reference yield:

: 917482-61-2
2',3'-isopropylidene-5-methyl-5'-O-t-butyldiphenylsilyluridine

: 917482-59-8
5-t-butyldiphenylsilyloxymethyl-5'-O-t-butyldiphenylsilyluridine 2',3'-bisxanthate

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-bromosuccinimide; benzoyl peroxide / CCl₄ / Heating

2.1: 491 mg / NaHCO₃ / H₂O; tetrahydrofuran / 20 °C

3.1: 24 percent / imidazole; DMAP / dimethylformamide / 20 °C

4.1: AcOH / H₂O / Heating

5.1: NaOH / dimethylsulfoxide; H₂O / 0.33 h / 20 °C

5.2: 41 percent / dimethylsulfoxide; H₂O / 1.5 h

With 1H-imidazole; dmap; sodium hydroxide; N-Bromosuccinimide; sodium hydrogencarbonate; acetic acid; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2006.09.083

Reference yield:

: 5-bromomethyl-1-[6-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-1H-pyrimidine-2,4-dione

: 917482-59-8
5-t-butyldiphenylsilyloxymethyl-5'-O-t-butyldiphenylsilyluridine 2',3'-bisxanthate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 491 mg / NaHCO₃ / H₂O; tetrahydrofuran / 20 °C

2.1: 24 percent / imidazole; DMAP / dimethylformamide / 20 °C

3.1: AcOH / H₂O / Heating

4.1: NaOH / dimethylsulfoxide; H₂O / 0.33 h / 20 °C

4.2: 41 percent / dimethylsulfoxide; H₂O / 1.5 h

With 1H-imidazole; dmap; sodium hydroxide; sodium hydrogencarbonate; acetic acid; In tetrahydrofuran; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2006.09.083